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Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active-site residues
Selection for a promiscuous enzyme activity provides substantial opportunity for competition
between endogenous and newly-encountered substrates to influence the evolutionary …
between endogenous and newly-encountered substrates to influence the evolutionary …
Characterisation and optimisation of nitroreductase-prodrug combinations for bacterial-directed enzyme-prodrug therapy
J Chan-Hyams - 2020 - openaccess.wgtn.ac.nz
Gene-directed enzyme-prodrug therapy (GDEPT) employs tumour-tropic vectors including
viruses (VDEPT) and bacteria (BDEPT) to deliver a genetically-encoded prodrug-converting …
viruses (VDEPT) and bacteria (BDEPT) to deliver a genetically-encoded prodrug-converting …
A giant leap in sequence space reveals the intracellular complexities of evolving a new function
Selection for a promiscuous enzyme activity provides substantial opportunity for competition
between endogenous and new substrates to influence the evolutionary trajectory, an aspect …
between endogenous and new substrates to influence the evolutionary trajectory, an aspect …