The K18-human ACE2 transgenic mouse model recapitulates non-severe and severe COVID-19 in response to an infectious dose of the SARS-CoV-2 virus
ABSTRACT A comprehensive analysis and characterization of a severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection model that mimics non-severe and severe …
syndrome coronavirus 2 (SARS-CoV-2) infection model that mimics non-severe and severe …
Contribution of SARS-CoV-2 accessory proteins to viral pathogenicity in K18 human ACE2 transgenic mice
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the viral pathogen
responsible for the current coronavirus disease 2019 (COVID-19) pandemic. As of 19 May …
responsible for the current coronavirus disease 2019 (COVID-19) pandemic. As of 19 May …
SARS-CoV-2 causes lung infection without severe disease in human ACE2 knock-in mice
The development of mouse models for coronavirus disease 2019 (COVID-19) has enabled
testing of vaccines and therapeutics and defining aspects of severe acute respiratory …
testing of vaccines and therapeutics and defining aspects of severe acute respiratory …
[HTML][HTML] SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein
R Khaddaj-Mallat, N Aldib, M Bernard… - Neurobiology of …, 2021 - Elsevier
Abstract Coronavirus disease 19 (COVID-19) is a respiratory illness caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2). COVID-19 pathogenesis causes …
respiratory syndrome coronavirus-2 (SARS-CoV-2). COVID-19 pathogenesis causes …
Sex differences in lung imaging and SARS-CoV-2 antibody responses in a COVID-19 golden Syrian hamster model
In the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), more severe outcomes are reported in …
respiratory syndrome coronavirus 2 (SARS-CoV-2), more severe outcomes are reported in …
A glycosylated RBD protein induces enhanced neutralizing antibodies against Omicron and other variants with improved protection against SARS-CoV-2 infection
ABSTRACT SARS-CoV-2 has mutated frequently since its first emergence in 2019.
Numerous variants, including the currently emerging Omicron variant, have demonstrated …
Numerous variants, including the currently emerging Omicron variant, have demonstrated …
Inhibition of autophagy suppresses SARS-CoV-2 replication and ameliorates pneumonia in hACE2 transgenic mice and xenografted human lung tissues
C Shang, X Zhuang, H Zhang, Y Li, Y Zhu, J Lu… - Journal of …, 2021 - Am Soc Microbiol
Autophagy is thought to be involved in severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection. However, how SARS-CoV-2 interferes with the autophagic pathway …
(SARS-CoV-2) infection. However, how SARS-CoV-2 interferes with the autophagic pathway …
Efficacy of GC-376 against SARS-CoV-2 virus infection in the K18 hACE2 transgenic mouse model
The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2
(SARS-CoV-2) is the defining global health emergency of this century. GC-376 is a Mpro …
(SARS-CoV-2) is the defining global health emergency of this century. GC-376 is a Mpro …
The Delta SARS-CoV-2 variant of concern induces distinct pathogenic patterns of respiratory disease in K18-hACE2 transgenic mice compared to the ancestral strain …
Compared to the original ancestral strain of SARS-CoV-2, the Delta variant of concern has
shown increased transmissibility and resistance toward COVID-19 vaccines and therapies …
shown increased transmissibility and resistance toward COVID-19 vaccines and therapies …
Kinetic multi-omic analysis of responses to SARS-CoV-2 infection in a model of severe COVID-19
The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
poorly understood due to a lack of an animal model that recapitulates severe human …
poorly understood due to a lack of an animal model that recapitulates severe human …