Benzodiazepines in the management of seizures and status epilepticus: a review of routes of delivery, pharmacokinetics, efficacy, and tolerability

R Kienitz, L Kay, I Beuchat, S Gelhard… - CNS drugs, 2022 - Springer
Status epilepticus (SE) is an acute, life-threatening medical condition that requires
immediate, effective therapy. Therefore, the acute care of prolonged seizures and SE is a …

Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus

RJ Burman, RE Rosch, JM Wilmshurst, A Sen… - Nature Reviews …, 2022 - nature.com
Status epilepticus is a life-threatening neurological emergency that affects both adults and
children. Approximately 36% of episodes of status epilepticus do not respond to the current …

[HTML][HTML] Lower urinary tract symptoms in depression: a review

DJ Anderson, A Aucoin, CR Toups… - Health psychology …, 2023 - ncbi.nlm.nih.gov
Abstract Lower Urinary Tract Symptoms (LUTS) are frequently present in the general
population as patients age with approximately a third of individuals experiencing LUTS …

Trends and differences in status epilepticus treatment of children and adults over 10 years: A comparative study of medical records (2012–2021) from a University …

L Purwien, S Schubert-Bast, M Kieslich… - CNS drugs, 2023 - Springer
Abstract Background and Objectives Over the last decade, significant advancements have
been made in status epilepticus (SE) management, influenced by landmark trials such as …

Intranasal midazolam versus intravenous/rectal benzodiazepines for acute seizure control in children: a systematic review and meta-analysis

R Chhabra, R Gupta, LK Gupta - Epilepsy & Behavior, 2021 - Elsevier
Background Acute seizure activity might cause complications including bodily harm,
progression to status epilepticus, and poor quality of life in children. The introduction of a …

Benzodiazepines for the treatment of seizure clusters

PE Penovich, VR Rao, L Long, E Carrazana… - CNS drugs, 2024 - Springer
Patients with epilepsy may experience seizure clusters, which are described by the US Food
and Drug Administration (FDA) as intermittent, stereotypic episodes of frequent seizure …

Efficacy, tolerability, and safety of concentrated intranasal midazolam spray as emergency medication in epilepsy patients during video-EEG monitoring

A von Blomberg, L Kay, S Knake, S Fuest, JP Zöllner… - CNS drugs, 2020 - Springer
Background An efficient, well tolerated, and safe emergency treatment with a rapid onset of
action is needed to prevent seizure clusters and to terminate prolonged seizures and status …

Update on the management of status epilepticus

AO Rossetti, V Alvarez - Current opinion in neurology, 2021 - journals.lww.com
There is a continuous, albeit relatively slow progress in knowledge regarding different
aspect of status epilepticus; recent findings refine some treatment strategies and help …

[HTML][HTML] The nose has it: Opportunities and challenges for intranasal drug administration for neurologic conditions including seizure clusters

S Chung, JM Peters, K Detyniecki, W Tatum… - Epilepsy & behavior …, 2023 - Elsevier
Nasal administration of treatments for neurologic conditions, including rescue therapies to
treat seizure clusters among people with epilepsy, represents a meaningful advance in …

Prolonged mechanical ventilation in patients with terminated status epilepticus and outcome: an observational cohort study

SM Baumann, S Semmlack, A Rybitschka… - …, 2021 - Wiley Online Library
Objective Classical clinical characteristics associated with successful or unsuccessful
extubation are unreliable in neurocritically ill patients, and attempts to predict successful …