Clinical trial design, end-points, and emerging therapies in pulmonary arterial hypertension
Clinical trials in pulmonary arterial hypertension (PAH) have led to the approval of several
effective treatments that improve symptoms, exercise capacity and clinical outcomes. In …
effective treatments that improve symptoms, exercise capacity and clinical outcomes. In …
The evolution of clinical trials for pediatric pulmonary hypertension: are the needs of patients and their caregivers being met?
Introduction Pediatric pulmonary hypertension is a rare condition. Survival remains poor in
the current management era. There is a lack of data regarding the medical management of …
the current management era. There is a lack of data regarding the medical management of …
Analysis of Terminated Pulmonary Hypertension Clinical Trials. What Are We Doing Wrong?
Despite significant interest in the diagnosis and treatment of pulmonary hypertension (PH)
over the past two decades, there have been no notable advancements in reducing mortality …
over the past two decades, there have been no notable advancements in reducing mortality …
Win Statistics in Pulmonary Arterial Hypertension Clinical Trials
Methods We performed a meta-analysis of individual participant data from 18 phase III
randomized clinical trials of therapies for PAH submitted to the US Food and Drug …
randomized clinical trials of therapies for PAH submitted to the US Food and Drug …
Ambitions for Pulmonary Arterial Hypertension Composite End Points: A Chain Is Only as Strong as Its Weakest Link
The recent European Cardiology Society/European Respiratory Society clinical guidelines
for the treatment of pulmonary arterial hypertension (PAH) recommend that selection of …
for the treatment of pulmonary arterial hypertension (PAH) recommend that selection of …