The sigma-1 receptor as a pluripotent modulator in living systems
The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum (ER) protein that resides
specifically in the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) …
specifically in the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) …
[HTML][HTML] Neuronal sigma-1 receptors: signaling functions and protective roles in neurodegenerative diseases
Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …
Calcium-permeable ion channels in pain signaling
The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
The pharmacology of sigma-1 receptors
T Maurice, TP Su - Pharmacology & therapeutics, 2009 - Elsevier
Originally considered an enigmatic protein, the sigma-1 receptor has recently been
identified as a unique ligand-regulated molecular chaperone in the endoplasmic reticulum …
identified as a unique ligand-regulated molecular chaperone in the endoplasmic reticulum …
The molecular function of σ receptors: past, present, and future
HR Schmidt, AC Kruse - Trends in pharmacological sciences, 2019 - cell.com
The σ 1 and σ 2 receptors are enigmatic proteins that have attracted attention for decades
due to the chemical diversity and therapeutic potential of their ligands. However, despite …
due to the chemical diversity and therapeutic potential of their ligands. However, despite …
Acid-sensing ion channels (ASICs): pharmacology and implication in pain
Tissue acidosis is a common feature of many painful conditions. Protons are indeed among
the first factors released by injured tissues, inducing a local pH fall that depolarizes …
the first factors released by injured tissues, inducing a local pH fall that depolarizes …
Therapeutic inhibition of acid-sensing ion channel 1a recovers heart function after ischemia–reperfusion injury
Background: Ischemia–reperfusion injury (IRI) is one of the major risk factors implicated in
morbidity and mortality associated with cardiovascular disease. During cardiac ischemia, the …
morbidity and mortality associated with cardiovascular disease. During cardiac ischemia, the …
The sigma-1 receptor: roles in neuronal plasticity and disease
Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and psychiatric
conditions. Sig-1Rs are intracellular chaperones that reside specifically at the endoplasmic …
conditions. Sig-1Rs are intracellular chaperones that reside specifically at the endoplasmic …
Sigmar1's molecular, cellular, and biological functions in regulating cellular pathophysiology
The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …
[HTML][HTML] Potential applications for sigma receptor ligands in cancer diagnosis and therapy
A van Waarde, AA Rybczynska… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Sigma receptors (sigma-1 and sigma-2) represent two independent classes of proteins.
Their endogenous ligands may include the hallucinogen N, N-dimethyltryptamine (DMT) …
Their endogenous ligands may include the hallucinogen N, N-dimethyltryptamine (DMT) …