The role of the phosphorus atom in drug design
Although the phosphorus atom is found in a variety of oxidation states, most of the
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …
Role of metabolism in bone development and homeostasis
Carbohydrates, fats, and proteins are the underlying energy sources for animals and are
catabolized through specific biochemical cascades involving numerous enzymes. The …
catabolized through specific biochemical cascades involving numerous enzymes. The …
Advances in preclinical approaches to Chagas disease drug discovery
F Villalta, G Rachakonda - Expert opinion on drug discovery, 2019 - Taylor & Francis
ABSTRACT Introduction: Chagas disease affects 8–10 million people worldwide, mainly in
Latin America. The current therapy for Chagas disease is limited to nifurtimox and …
Latin America. The current therapy for Chagas disease is limited to nifurtimox and …
Chiral Organophosphorus Pharmaceuticals: Properties and Application
This review considers the chiral phosphorus-containing drugs used to treat patients in the
clinic, as well as the promising and experimental drugs that are in the process of being …
clinic, as well as the promising and experimental drugs that are in the process of being …
An updated review of chemical compounds with anti-Toxoplasma gondii activity
The opportunistic apicomplexan parasite Toxoplasma gondii is the etiologic agent for
toxoplasmosis, which can infect a widespread range of hosts, particularly humans and warm …
toxoplasmosis, which can infect a widespread range of hosts, particularly humans and warm …
Carbonic anhydrases from Trypanosoma and Leishmania as anti-protozoan drug targets
Trypanosoma cruzi and Leishmania spp. are protozoa of the Trypanosomatidae family,
being the etiological agents of two widespread parasitic diseases, Chagas disease and …
being the etiological agents of two widespread parasitic diseases, Chagas disease and …
Trypanothione reductase and superoxide dismutase as current drug targets for Trypanosoma cruzi: an overview of compounds with activity against Chagas disease
I Beltran-Hortelano, S Perez-Silanes… - Current Medicinal …, 2017 - ingentaconnect.com
It has been over a century since Carlos Chagas discovered the Trypanosoma cruzi (T. cruzi)
as the causative agent of Chagas disease (CD), a neglected tropical disease with several …
as the causative agent of Chagas disease (CD), a neglected tropical disease with several …
QSAR models for nitrogen containing monophosphonate and bisphosphonate derivatives as human farnesyl pyrophosphate synthase inhibitors based on Monte …
Human farnesyl pyrophosphate synthase (hFPPS) is a well-settled therapeutic target and it
is an enzyme of the mevalonate pathway which catalyzes the biosynthesis of the C-15 …
is an enzyme of the mevalonate pathway which catalyzes the biosynthesis of the C-15 …
Metabolic changes in tumor microenvironment: how could they affect γδ T cells functions?
The metabolic changes that occur in tumor microenvironment (TME) can influence not only
the biological activity of tumor cells, which become more aggressive and auto sustained, but …
the biological activity of tumor cells, which become more aggressive and auto sustained, but …
Expanding the scope of novel 1, 2, 3-triazole derivatives as new antiparasitic drug candidates
R Carlucci, G Di Gresia, MG Mediavilla… - RSC Medicinal …, 2023 - pubs.rsc.org
We have previously shown that prenyl and aliphatic triazoles are interesting motifs to
prepare new chemical entities for antiparasitic and antituberculosis drug development. In …
prepare new chemical entities for antiparasitic and antituberculosis drug development. In …