Neurodegenerative diseases (NDs) are characterized by the aggregation of neurotoxic
proteins in the central nervous system. Aberrant protein accumulation in NDs is largely …

Abstract Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that
sustains proteostasis network under a large variety of physiopathological conditions. Its …

Alzheimer's disease (AD) is characterized by toxic protein accumulation in the brain.
Ubiquitination is essential for protein clearance in cells, making altered ubiquitin signaling …

Argyrophilic grain disease (AGD) is a common sporadic neurodegenerative disease of old
age characterized by the presence of argyrophilic grains (AGs)—dendritic-derived …

Mutations in three genes (PSEN1, PSEN2, and APP) have been identified in patients with
early-onset (< 65years) Alzheimer's disease (AD). We performed a screening for mutations …

As neurons age, their survival depends on eliminating a growing burden of damaged,
potentially toxic proteins and organelles—a capability that declines owing to aging and …

Alzheimer's disease (AD) is the most common form of dementia, most prevalent in the
elderly population and has a significant impact on individuals and their family as well as the …

Sporadic inclusion-body myositis (s-IBM), the most common muscle disease of older
persons, is of unknown cause and there is no successful treatment. We summarize our most …

The ubiquitin proteasome system (UPS) is the major protein quality control system in
eukaryotic cells. Many neurodegenerative diseases are characterized by aggregates and …

Argyrophilic grain disease (AgD) is a late‐onset dementia morphologically characterized by
the presence of abundant spindle‐shaped argyrophilic grains (ArG) in neuronal processes …