Desmosomes are relatives of ancient cadherin-based junctions, which emerged late in
evolution to ensure the structural integrity of vertebrate tissues by coupling the intermediate …

Caffeic acid (CA) is a polyphenol belonging to the phenylpropanoid family, commonly found
in plants and vegetables. It was first identified by Hlasiwetz in 1867 as a breakdown product …

Background & Aims In the develo** liver, bipotent epithelial progenitor cells undergo
lineage segregation to form hepatocytes, which constitute the bulk of the liver parenchyma …

Keratinocytes are major cellular components of the skin and are strongly involved in its
homeostasis. Oncogenic events, starting mainly from excessive sun exposure, lead to the …

Stem cells (SCs) are critical to maintain tissue homeostasis. However, it is currently not
known whether signaling through cell junctions protects quiescent epithelial SC reservoirs …

The keratin cytoskeleton protects epithelia against mechanical, nonmechanical, and
physical stresses, and participates in multiple signaling pathways that regulate cell integrity …

Sweat is an essential protection system for the body, but its failure can result in pathologic
conditions, including several skin diseases, such as palmoplantar pustulosis (PPP). As …

Abnormal nuclear enlargement is a diagnostic and physical hallmark of malignant tumors.
Large nuclei are positively associated with an increased risk of develo** metastasis; …

Loss of CDH1/Cadherin-1 is a common step towards the acquisition of an abnormal
epithelial phenotype. In gastric cancer (GC), mutation and/or downregulation of …

S-acylation, which includes S-palmitoylation, is the only known reversible lipid-based post-
translational protein modification. S-palmitoylation is mediated by palmitoyl acyltransferases …