Mammalian target of rapamycin (mTOR) regulates cell proliferation, autophagy, and
apoptosis by participating in multiple signaling pathways in the body. Studies have shown …

Oncogenic KRAS mutation-driven pancreatic ductal adenocarcinoma is currently the fourth-
leading cause of cancer-related deaths in the United States. Macroautophagy (hereafter …

Oxidative stress and cardiomyocyte apoptosis are involved in the pathogenesis of
doxorubicin (DOX)-induced cardiotoxicity. Matrine is well-known for its powerful anti-oxidant …

Simple Summary The metabolism of carbohydrates and lipids is essential to meet the
diverse needs of cells. The autophagy cellular pathway is crucial for normal cellular function …

Blue synthetic dyes are widely used in many industries. Although they are approved for use
as food dyes and in cosmetics and some medicines, their impacts on consumer health …

Oxidative stress is a state of imbalance between oxidation and antioxidation. Excessive ROS
levels are an important factor in tumor development. Damage stimulation and excessive …

Several studies indicate that the cytosolic enzyme glyceraldehyde-3-phosphate
dehydrogenase (GAPDH) has pleiotropic functions independent of its canonical role in …

For centuries, plants have been exploited by mankind as sources of numerous cancer
chemotherapeutic agents. Good examples of anticancer compounds of clinical significance …

This study aimed to explore the protective roles of malvidin in life-threatened sepsis-
associated encephalopathy (SAE) and illustrate the underlying mechanism. SAE mice …

Ovarian cancer is the deadliest gynecological cancer in women, with a survival rate of less
than 30% when the cancer has spread throughout the peritoneal cavity. Aggregation of …