Neutrophil phenotypes and functions in cancer: A consensus statement
Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …
component of innate immune defense. Understanding the behavior of neutrophils as they …
Decoding the tumor microenvironment with spatial technologies
LA Walsh, DF Quail - Nature Immunology, 2023 - nature.com
Visualization of the cellular heterogeneity and spatial architecture of the tumor
microenvironment (TME) is becoming increasingly important to understand mechanisms of …
microenvironment (TME) is becoming increasingly important to understand mechanisms of …
Circadian rhythms and cancers: the intrinsic links and therapeutic potentials
The circadian rhythm is an evolutionarily conserved time-kee** system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …
Circadian regulation of drug responses: toward sex-specific and personalized chronotherapy
Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …
Foundations of circadian medicine
The circadian clock is an evolutionarily highly conserved endogenous timing program that
structures physiology and behavior according to the time of day. Disruption of circadian …
structures physiology and behavior according to the time of day. Disruption of circadian …
Improvement of the anticancer efficacy of PD-1/PD-L1 blockade via combination therapy and PD-L1 regulation
M Wu, Q Huang, Y **e, X Wu, H Ma, Y Zhang… - Journal of hematology & …, 2022 - Springer
Immune checkpoint molecules are promising anticancer targets, among which therapeutic
antibodies targeting the PD-1/PD-L1 pathway have been widely applied to cancer treatment …
antibodies targeting the PD-1/PD-L1 pathway have been widely applied to cancer treatment …
Chronotherapy: circadian rhythms and their influence in cancer therapy
A Amiama-Roig, EM Verdugo-Sivianes, A Carnero… - Cancers, 2022 - mdpi.com
Simple Summary Living organisms present rhythmic fluctuations every 24 h in their behavior
and metabolism to anticipate changes in the environment. These fluctuations are controlled …
and metabolism to anticipate changes in the environment. These fluctuations are controlled …
Time-dependent efficacy of checkpoint inhibitor nivolumab: results from a pilot study in patients with metastatic non-small-cell lung cancer
A Karaboué, T Collon, I Pavese, V Bodiguel… - Cancers, 2022 - mdpi.com
Simple Summary Initial clinical observations revealed strikingly longer follow-up for
metastatic non-small-cell lung cancer (NSCLC) patients receiving nivolumab infusions …
metastatic non-small-cell lung cancer (NSCLC) patients receiving nivolumab infusions …
Carbon monoxide signaling: examining its engagement with various molecular targets in the context of binding affinity, concentration, and biologic response
Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule
with a variety of pathophysiological and pharmacological functions, including …
with a variety of pathophysiological and pharmacological functions, including …
Circadian immunity from bench to bedside: a practical guide
H Mok, E Ostendorf, A Ganninger… - The Journal of …, 2024 - Am Soc Clin Investig
The immune system is built to counteract unpredictable threats, yet it relies on predictable
cycles of activity to function properly. Daily rhythms in immune function are an expanding …
cycles of activity to function properly. Daily rhythms in immune function are an expanding …