Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and
progression. In this review, we update currents concepts of hypoxia-induced alternative …

In cell and molecular biology, metabolism is the only system that can be fully simulated at
genome scale. Metabolic systems biology offers powerful abstraction tools to simulate all …

Mitochondria are crucial bioenergetics powerhouses and biosynthetic hubs within cells,
which can generate and sequester toxic reactive oxygen species (ROS) in response to …

Neutrophils are the most abundant leukocytes in humans and play a role in the innate
immune response by being the first cells attracted to the site of infection. While early studies …

Lactate dehydrogenase (LDH) is being increasingly recognized as a major factor in the
progression of breast cancer. It was previously shown that short interfering RNA-mediated …

Trimetazidine (TMZ), used for treating stable angina pectoris, has garnered attention in the
realm of sports due to its potential performance-enhancing properties, and the World Anti …

In human metabolism, pyruvate dehydrogenase complex (PDC) is one of the most intricate
and large multimeric protein systems representing a central hub for cellular homeostasis …

Personalized medicine requires large cohorts for patient stratification and validation of
patient clustering. However, standards and harmonized practices on the methods and tools …

Simple Summary MicroRNAs are small non-coding RNAs that regulate gene expression.
Single Nucleotide Polymorphisms (SNPs), which have been previously associated with …

Background Ageing can be classified in two different ways, chronological ageing and
biological ageing. While chronological age is a measure of the time that has passed since …