The bacterial epigenome
In all domains of life, genomes contain epigenetic information superimposed over the
nucleotide sequence. Epigenetic signals control DNA–protein interactions and can cause …
nucleotide sequence. Epigenetic signals control DNA–protein interactions and can cause …
Deciphering bacterial epigenomes using modern sequencing technologies
J Beaulaurier, EE Schadt, G Fang - Nature Reviews Genetics, 2019 - nature.com
Prokaryotic DNA contains three types of methylation: N6-methyladenine, N4-methylcytosine
and 5-methylcytosine. The lack of tools to analyse the frequency and distribution of …
and 5-methylcytosine. The lack of tools to analyse the frequency and distribution of …
Map** DNA methylation with high-throughput nanopore sequencing
DNA chemical modifications regulate genomic function. We present a framework for
map** cytosine and adenosine methylation with the Oxford Nanopore Technologies …
map** cytosine and adenosine methylation with the Oxford Nanopore Technologies …
The epigenomic landscape of prokaryotes
DNA methylation acts in concert with restriction enzymes to protect the integrity of
prokaryotic genomes. Studies in a limited number of organisms suggest that methylation …
prokaryotic genomes. Studies in a limited number of organisms suggest that methylation …
De novo Identification of DNA Modifications Enabled by Genome-Guided Nanopore Signal Processing
Advances in nanopore sequencing technology have enabled investigation of the full
catalogue of covalent DNA modifications. We present the first algorithm for the identification …
catalogue of covalent DNA modifications. We present the first algorithm for the identification …
Genome-wide map** of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing
G Fang, D Munera, DI Friedman, A Mandlik… - Nature …, 2012 - nature.com
Single-molecule real-time (SMRT) DNA sequencing allows the systematic detection of
chemical modifications such as methylation but has not previously been applied on a …
chemical modifications such as methylation but has not previously been applied on a …
Nucleic acid modifications in regulation of gene expression
Nucleic acids carry a wide range of different chemical modifications. In contrast to previous
views that these modifications are static and only play fine-tuning functions, recent research …
views that these modifications are static and only play fine-tuning functions, recent research …
DNA methylation in bacteria: from the methyl group to the methylome
Highlights•Bacterial genomes contain C 5-methyl-cytosine, N 4-methyl-cytosine, and N 6-
methyl-adenine.•Base methylation controls DNA–protein interactions.•DNA methylation …
methyl-adenine.•Base methylation controls DNA–protein interactions.•DNA methylation …
DNA methyltransferases and epigenetic regulation in bacteria
S Adhikari, PD Curtis - FEMS microbiology reviews, 2016 - academic.oup.com
Epigenetics is a change in gene expression that is heritable without a change in DNA
sequence itself. This phenomenon is well studied in eukaryotes, particularly in humans for …
sequence itself. This phenomenon is well studied in eukaryotes, particularly in humans for …
To be or not to be: regulation of restriction–modification systems and other toxin–antitoxin systems
I Mruk, I Kobayashi - Nucleic acids research, 2014 - academic.oup.com
One of the simplest classes of genes involved in programmed death is that containing the
toxin–antitoxin (TA) systems of prokaryotes. These systems are composed of an intracellular …
toxin–antitoxin (TA) systems of prokaryotes. These systems are composed of an intracellular …