Obsessive-compulsive disorder: puzzles and prospects
Obsessive-compulsive disorder is a severe and disabling psychiatric disorder that presents
several challenges for neuroscience. Recent advances in its genetic and developmental …
several challenges for neuroscience. Recent advances in its genetic and developmental …
Harmonizing the neurobiology and treatment of obsessive-compulsive disorder
Obsessive-compulsive disorder (OCD) is a common, chronic, and oftentimes disabling
disorder. The only established first-line treatments for OCD are exposure and response …
disorder. The only established first-line treatments for OCD are exposure and response …
Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis
D Posthuma - Molecular psychiatry, 2018 - research.vu.nl
Two obsessive-compulsive disorder (OCD) genome-wide association studies (GWASs)
have been published by independent OCD consortia, the International Obsessive …
have been published by independent OCD consortia, the International Obsessive …
Meta-analysis of genome-wide association studies of anxiety disorders
Anxiety disorders (ADs), namely generalized AD, panic disorder and phobias, are common,
etiologically complex conditions with a partially genetic basis. Despite differing on diagnostic …
etiologically complex conditions with a partially genetic basis. Despite differing on diagnostic …
Obsessive–compulsive disorder: an integrative genetic and neurobiological perspective
Obsessive–compulsive disorder (OCD) is characterized by repetitive thoughts and
behaviours that are experienced as unwanted. Family and twin studies have demonstrated …
behaviours that are experienced as unwanted. Family and twin studies have demonstrated …
Genetics of obsessive-compulsive disorder
BackgroundObsessive-compulsive disorder (OCD) is a psychiatric disorder with multiple
symptom dimensions (eg contamination, symmetry). OCD clusters in families and decades …
symptom dimensions (eg contamination, symmetry). OCD clusters in families and decades …
Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS
M Mattheisen, JF Samuels, Y Wang… - Molecular …, 2015 - nature.com
Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by intrusive
thoughts and urges and repetitive, intentional behaviors that cause significant distress and …
thoughts and urges and repetitive, intentional behaviors that cause significant distress and …
Striatal circuits, habits, and implications for obsessive–compulsive disorder
Highlights•Involvement of corticostriatal circuits in OCD is receiving strong new experimental
support.•This evidence is concordant with clinical evidence based on OCD patient …
support.•This evidence is concordant with clinical evidence based on OCD patient …
Self-domestication in Homo sapiens: Insights from comparative genomics
This study identifies and analyzes statistically significant overlaps between selective sweep
screens in anatomically modern humans and several domesticated species. The results …
screens in anatomically modern humans and several domesticated species. The results …
Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture
The direct estimation of heritability from genome-wide common variant data as implemented
in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to …
in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to …