Obsessive-compulsive disorder: puzzles and prospects

TW Robbins, MM Vaghi, P Banca - Neuron, 2019 - cell.com
Obsessive-compulsive disorder is a severe and disabling psychiatric disorder that presents
several challenges for neuroscience. Recent advances in its genetic and developmental …

Harmonizing the neurobiology and treatment of obsessive-compulsive disorder

WK Goodman, EA Storch… - American Journal of …, 2021 - Am Psychiatric Assoc
Obsessive-compulsive disorder (OCD) is a common, chronic, and oftentimes disabling
disorder. The only established first-line treatments for OCD are exposure and response …

Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis

D Posthuma - Molecular psychiatry, 2018 - research.vu.nl
Two obsessive-compulsive disorder (OCD) genome-wide association studies (GWASs)
have been published by independent OCD consortia, the International Obsessive …

Meta-analysis of genome-wide association studies of anxiety disorders

T Otowa, K Hek, M Lee, EM Byrne, SS Mirza… - Molecular …, 2016 - nature.com
Anxiety disorders (ADs), namely generalized AD, panic disorder and phobias, are common,
etiologically complex conditions with a partially genetic basis. Despite differing on diagnostic …

Obsessive–compulsive disorder: an integrative genetic and neurobiological perspective

DL Pauls, A Abramovitch, SL Rauch… - Nature Reviews …, 2014 - nature.com
Obsessive–compulsive disorder (OCD) is characterized by repetitive thoughts and
behaviours that are experienced as unwanted. Family and twin studies have demonstrated …

Genetics of obsessive-compulsive disorder

B Mahjani, K Bey, J Boberg, C Burton - Psychological Medicine, 2021 - cambridge.org
BackgroundObsessive-compulsive disorder (OCD) is a psychiatric disorder with multiple
symptom dimensions (eg contamination, symmetry). OCD clusters in families and decades …

Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS

M Mattheisen, JF Samuels, Y Wang… - Molecular …, 2015 - nature.com
Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by intrusive
thoughts and urges and repetitive, intentional behaviors that cause significant distress and …

Striatal circuits, habits, and implications for obsessive–compulsive disorder

E Burguiere, P Monteiro, L Mallet, G Feng… - Current opinion in …, 2015 - Elsevier
Highlights•Involvement of corticostriatal circuits in OCD is receiving strong new experimental
support.•This evidence is concordant with clinical evidence based on OCD patient …

Self-domestication in Homo sapiens: Insights from comparative genomics

C Theofanopoulou, S Gastaldon, T O'Rourke… - PloS one, 2017 - journals.plos.org
This study identifies and analyzes statistically significant overlaps between selective sweep
screens in anatomically modern humans and several domesticated species. The results …

Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture

LK Davis, D Yu, CL Keenan, ER Gamazon… - PLoS …, 2013 - journals.plos.org
The direct estimation of heritability from genome-wide common variant data as implemented
in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to …