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Fundamentals of microfluidic cell culture in controlled microenvironments
Microfluidics has the potential to revolutionize the way we approach cell biology research.
The dimensions of microfluidic channels are well suited to the physical scale of biological …
The dimensions of microfluidic channels are well suited to the physical scale of biological …
[HTML][HTML] Membrane fouling phenomena in microfluidic systems: from technical challenges to scientific opportunities
The almost ubiquitous, though undesired, deposition and accumulation of
suspended/dissolved matter on solid surfaces, known as fouling, represents a crucial issue …
suspended/dissolved matter on solid surfaces, known as fouling, represents a crucial issue …
Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner
Rupture of a vulnerable atherosclerotic plaque causes thrombus formation and precipitates
cardiovascular diseases. In addition to the thrombogenic content of a plaque, also the …
cardiovascular diseases. In addition to the thrombogenic content of a plaque, also the …
A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets
Hemostatic thrombi develop a characteristic architecture in which a core of highly activated
platelets is covered by a shell of less-activated platelets. Here we have used a systems …
platelets is covered by a shell of less-activated platelets. Here we have used a systems …
Irreversible, direct bonding of nanoporous polymer membranes to PDMS or glass microdevices
A method for integrating porous polymer membranes such as polycarbonate,
polyethersulfone and polyethylene terephthalate to microfluidic devices is described. The …
polyethersulfone and polyethylene terephthalate to microfluidic devices is described. The …
Native extracellular matrix-derived semipermeable, optically transparent, and inexpensive membrane inserts for microfluidic cell culture
Semipermeable cell culture membranes are commonly used in multilayered microfluidic
devices to mimic the basement membrane in vivo and to create compartmentalized …
devices to mimic the basement membrane in vivo and to create compartmentalized …
Microfluidics and coagulation biology
The study of blood ex vivo can occur in closed or open systems, with or without flow.
Microfluidic devices, which constrain fluids to a small (typically submillimeter) scale, facilitate …
Microfluidic devices, which constrain fluids to a small (typically submillimeter) scale, facilitate …
Translational nanomedicine: status assessment and opportunities
Nano-enabled technologies hold great promise for medicine and health. The rapid progress
by the physical sciences/engineering communities in synthesizing nanostructures and …
by the physical sciences/engineering communities in synthesizing nanostructures and …
Technology advancements in blood coagulation measurements for point-of-care diagnostic testing
In recent years, blood coagulation monitoring has become crucial to diagnosing causes of
hemorrhages, develo** anticoagulant drugs, assessing bleeding risk in extensive surgery …
hemorrhages, develo** anticoagulant drugs, assessing bleeding risk in extensive surgery …
Thrombin flux and wall shear rate regulate fibrin fiber deposition state during polymerization under flow
Thrombin is released as a soluble enzyme from the surface of platelets and tissue-factor-
bearing cells to trigger fibrin polymerization during thrombosis under flow conditions …
bearing cells to trigger fibrin polymerization during thrombosis under flow conditions …