Mitochondria, which serve as the energy factories of cells, are involved in cell differentiation,
calcium homeostasis, amino acid and fatty acid metabolism and apoptosis. In response to …

Apoptosis is a process of programmed cell death in which a cell commits suicide while
maintaining the integrity and architecture of the tissue as a whole. Apoptosis involves …

Autism spectrum disorder (ASD) is a highly heterogeneous disorder, yet transcriptomic
profiling of bulk brain tissue has identified substantial convergence among dysregulated …

Introduction Several pharmacoepidemiological studies indicate that proton pump inhibitors
(PPIs) significantly increase the risk of dementia. Yet, the underlying mechanism is not …

Introduction Cholinergic dysfunction, demonstrated in the late 1970s and early 1980s, led to
the introduction of acetylcholinesterase inhibitors (AChEIs) in 1993 (Tacrine) to enhance …

Mitochondria play a key role in cellular functions, including energy production and oxidative
stress regulation. For this reason, maintaining mitochondrial homeostasis and proteostasis …

Alzheimer's disease (AD) and related dementias are among the primary neurological
disorders and call for the urgent need for early-stage diagnosis to gain an upper edge in …

HtrA2/Omi is a mitochondrial serine protease with ascribed pro-apoptotic as well as pro-
necroptotic functions. Here, we establish that HtrA2/Omi also controls parthanatos, a third …

Colorectal cancer is the most common tumor of the gastrointestinal system. The
conventional treatment options for colorectal cancer are troublesome for both patients and …

The rare A673T variant was the first variant found within the amyloid precursor protein (APP)
gene conferring protection against Alzheimer's disease (AD). Thereafter, different studies …