Transcriptional regulation is essential for the correct functioning of cells during development
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …

The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct
neuron subtypes that mediate specific behaviours and are linked to various brain diseases …

Diabetes mellitus (DM) is considered to be a risk factor for dementia including Alzheimer's
disease (AD). However, the molecular mechanism underlying this risk is not well …

The consequences of injuries to the CNS are profound and persistent, resulting in
substantial burden to both the individual patient and society. Existing treatments for CNS …

In the develo** and mature brain, mitochondria act as central hubs for distinct but
interwined pathways, necessary for neural development, survival, activity, connectivity and …

The ability to directly reprogram mature cells to alternative fates challenges concepts of how
cell identities are maintained, erased, and acquired. Recent advances in understanding and …

Schizophrenia is associated with alterations in working memory that reflect dysfunction of
dorsolateral prefrontal cortex (DLPFC) circuitry. Working memory depends on the activity of …

The accumulation of misfolded α-synuclein (aSyn) and neuron loss define several
neurodegenerative disorders including Parkinson's disease (PD) and dementia with Lewy …

In normal brain, neurons in the cortex and hippocampus produce insulin, which modulates
glucose metabolism and cognitive functions. It has been shown that insulin resistance …

Spinal cord injury (SCI) is a serious problem in the central nervous system resulting in high
disability and mortality with complex pathophysiological mechanisms. Oxidative stress is …