The role of HOX genes in normal hematopoiesis and acute leukemia

RA Alharbi, R Pettengell, HS Pandha, R Morgan - Leukemia, 2013 - nature.com
The homeobox (HOX) genes are a highly conserved family of homeodomain-containing
transcription factors that specify cell identity in early development and, subsequently, in a …

[HTML][HTML] Hox genes and regional patterning of the vertebrate body plan

M Mallo, DM Wellik, J Deschamps - Developmental biology, 2010 - Elsevier
Several decades have passed since the discovery of Hox genes in the fruit fly Drosophila
melanogaster. Their unique ability to regulate morphologies along the anteroposterior (AP) …

Evolution of homeobox genes

PWH Holland - Wiley Interdisciplinary Reviews: Developmental …, 2013 - Wiley Online Library
Many homeobox genes encode transcription factors with regulatory roles in animal and
plant development. Homeobox genes are found in almost all eukaryotes, and have …

[КНИГА][B] Biology's first law: the tendency for diversity and complexity to increase in evolutionary systems

DW McShea, RN Brandon - 2010 - books.google.com
Life on earth is characterized by three striking phenomena that demand explanation:
adaptation—the marvelous fit between organism and environment; diversity—the great …

The genesis and evolution of homeobox gene clusters

J Garcia-Fernàndez - Nature Reviews Genetics, 2005 - nature.com
Once called the'Rosetta stone'of developmental biology, the homeobox continues to
fascinate both evolutionary and developmental biologists. The birth of the homeotic, or Hox …

Gene-balanced duplications, like tetraploidy, provide predictable drive to increase morphological complexity

M Freeling, BC Thomas - Genome research, 2006 - genome.cshlp.org
Controversy surrounds the apparent rising maximums of morphological complexity during
eukaryotic evolution, with organisms increasing the number and nestedness of …

Six major steps in animal evolution: are we derived sponge larvae?

C Nielsen - Evolution & development, 2008 - Wiley Online Library
SUMMARY A review of the old and new literature on animal morphology/embryology and
molecular studies has led me to the following scenario for the early evolution of the …

Pre-Bilaterian Origins of the Hox Cluster and the Hox Code: Evidence from the Sea Anemone, Nematostella vectensis

JF Ryan, ME Mazza, K Pang, DQ Matus, AD Baxevanis… - PloS one, 2007 - journals.plos.org
Background Hox genes were critical to many morphological innovations of bilaterian
animals. However, early Hox evolution remains obscure. Phylogenetic, developmental, and …

The Wnt code: cnidarians signal the way

C Guder, I Philipp, T Lengfeld, H Watanabe… - Oncogene, 2006 - nature.com
Cnidarians are the simplest metazoans with a nervous system. They are well known for their
regeneration capacity, which is based on the restoration of a signalling centre (organizer) …