Matrix effects can significantly impede the accuracy, sensitivity, and reliability of separation
techniques presenting a formidable challenge to the analytical process. It is crucial to …

Hydrogen isotopes are unique tools for identifying and understanding biological and
chemical processes. Hydrogen isotope labelling allows for the traceless and direct …

The consequences of matrix effects in mass spectrometry analysis are a major issue of
concern to analytical chemists. The identification of any ion suppressing (or enhancing) …

In recent decades, mass spectrometry techniques, particularly when combined with
separation methods such as high-performance liquid chromatography, have become …

The ability to quantify levels of target analytes in biological samples accurately and precisely
in biomonitoring involves the use of highly sensitive and selective instrumentation such as …

Matrix‐dependent signal suppression or enhancement represents a major drawback in
quantitative analysis with liquid chromatography coupled to atmospheric pressure ionization …

During recent years matrix effects in liquid chromatography coupled to tandem mass
spectrometry (LC–MS/MS) have quickly become a major concern in food analysis. The …

Liquid chromatography coupled to atmospheric pressure ionization tandem mass
spectrometry is currently the method of choice for the quantitative determination of drugs in …

Current methodologies for protein quantitation include 2-dimensional gel electrophoresis
techniques, metabolic labeling, and stable isotope labeling methods to name only a few …

A simple experimental approach for studying and identifying the relative matrix effect (for
example “plasma-to-plasma” and/or “urine-to-urine”) in quantitative analyses by HPLC …