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Risk factors of severe COVID-19: a review of host, viral and environmental factors
The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …
asymptomatic infections to severe disease and death. Understanding the risk factors of …
In search of a pan-coronavirus vaccine: Next-generation vaccine design and immune mechanisms
S Cankat, MU Demael, L Swadling - Cellular & molecular immunology, 2024 - nature.com
Members of the coronaviridae family are endemic to human populations and have caused
several epidemics and pandemics in recent history. In this review, we will discuss the …
several epidemics and pandemics in recent history. In this review, we will discuss the …
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2
Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) do not necessarily develop PCR or antibody positivity, suggesting that some …
(SARS-CoV-2) do not necessarily develop PCR or antibody positivity, suggesting that some …
Human coronavirus OC43-elicited CD4+ T cells protect against SARS-CoV-2 in HLA transgenic mice
RP dos Santos Alves, J Timis, R Miller… - Nature …, 2024 - nature.com
Abstract SARS-CoV-2-reactive T cells are detected in some healthy unexposed individuals.
Human studies indicate these T cells could be elicited by the common cold coronavirus …
Human studies indicate these T cells could be elicited by the common cold coronavirus …
Airway-resident T cells from unexposed individuals cross-recognize SARS-CoV-2
T cells can contribute to clearance of respiratory viruses that cause acute-resolving
infections such as SARS-CoV-2, hel** to provide long-lived protection against disease …
infections such as SARS-CoV-2, hel** to provide long-lived protection against disease …
Coronavirus disease 2019 in children
M Borrelli, A Corcione, F Castellano… - Frontiers in …, 2021 - frontiersin.org
Since its appearance in Wuhan in mid-December 2019, acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) related 19 coronavirus disease (COVID-19) has spread …
coronavirus 2 (SARS-CoV-2) related 19 coronavirus disease (COVID-19) has spread …
Functional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age
Pre-existing SARS-CoV-2-reactive T cells have been identified in SARS-CoV-2-unexposed
individuals, potentially modulating COVID-19 and vaccination outcomes. Here, we provide …
individuals, potentially modulating COVID-19 and vaccination outcomes. Here, we provide …
Cross-protection induced by highly conserved human B, CD4+, and CD8+ T-cell epitopes-based vaccine against severe infection, disease, and death caused by …
Background The coronavirus disease 2019 (COVID-19) pandemic has created one of the
largest global health crises in almost a century. Although the current rate of Severe acute …
largest global health crises in almost a century. Although the current rate of Severe acute …
SARS-CoV-2-specific CD4+ and CD8+ T cell responses can originate from cross-reactive CMV-specific T cells
CR Pothast, RC Dijkland, M Thaler, RS Hagedoorn… - Elife, 2022 - elifesciences.org
Detection of SARS-coronavirus-2 (SARS-CoV-2) specific CD4+ and CD8+ T cells in SARS-
CoV-2-unexposed donors has been explained by the presence of T cells primed by other …
CoV-2-unexposed donors has been explained by the presence of T cells primed by other …
SARS-CoV-2–specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens
The baseline composition of T cells directly affects later response to pathogens, but the
complexity of precursor states remains poorly defined. Here, we examined the baseline state …
complexity of precursor states remains poorly defined. Here, we examined the baseline state …