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Lipid-based nanoparticles in the clinic and clinical trials: from cancer nanomedicine to COVID-19 vaccines
COVID-19 vaccines have been developed with unprecedented speed which would not have
been possible without decades of fundamental research on delivery nanotechnology. Lipid …
been possible without decades of fundamental research on delivery nanotechnology. Lipid …
Solid lipid nanoparticles vs. nanostructured lipid carriers: a comparative review
Solid–lipid nanoparticles and nanostructured lipid carriers are delivery systems for the
delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures …
delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures …
Astaxanthin activated the Nrf2/HO-1 pathway to enhance autophagy and inhibit ferroptosis, ameliorating acetaminophen-induced liver injury
X Cai, S Hua, J Deng, Z Du, D Zhang… - … Applied Materials & …, 2022 - ACS Publications
Acetaminophen (APAP)-induced liver injury (AILI) is a common liver disease in clinical
practice. Only one clinically approved drug, N-acetylcysteine (NAC), for the treatment of AILI …
practice. Only one clinically approved drug, N-acetylcysteine (NAC), for the treatment of AILI …
Strategies for structural modification of small molecules to improve blood–brain barrier penetration: a recent perspective
B **ong, Y Wang, Y Chen, S **ng, Q Liao… - Journal of Medicinal …, 2021 - ACS Publications
In the development of central nervous system (CNS) drugs, the blood–brain barrier (BBB)
restricts many drugs from entering the brain to exert therapeutic effects. Although many …
restricts many drugs from entering the brain to exert therapeutic effects. Although many …
Nanotherapeutics for nose-to-brain drug delivery: an approach to bypass the blood brain barrier
D Lee, T Minko - Pharmaceutics, 2021 - mdpi.com
Treatment of neurodegenerative diseases or other central nervous system (CNS) disorders
has always been a significant challenge. The nature of the blood-brain barrier (BBB) limits …
has always been a significant challenge. The nature of the blood-brain barrier (BBB) limits …
Current status and challenges associated with CNS-targeted gene delivery across the BBB
S Kimura, H Harashima - Pharmaceutics, 2020 - mdpi.com
The era of the aging society has arrived, and this is accompanied by an increase in the
absolute numbers of patients with neurological disorders, such as Alzheimer's disease (AD) …
absolute numbers of patients with neurological disorders, such as Alzheimer's disease (AD) …
Promising nanotechnology approaches in treatment of autoimmune diseases of central nervous system
Multiple sclerosis (MS) is a chronic, autoimmune, neurodegenerative disease of the central
nervous system (CNS) that yields to neuronal axon damage, demyelization, and paralysis …
nervous system (CNS) that yields to neuronal axon damage, demyelization, and paralysis …
Compritol-based nanostrucutured lipid carriers (NLCs) for augmentation of zolmitriptan bioavailability via the transdermal route: in vitro optimization, ex vivo …
Migraine is a severe neurovascular disease manifested mainly as unilateral throbbing
headaches. Triptans are agonists for serotonin receptors. Zolmitriptan (ZMP) is a …
headaches. Triptans are agonists for serotonin receptors. Zolmitriptan (ZMP) is a …
[HTML][HTML] Strategies increasing the effectiveness of temozolomide at various levels of anti-GBL therapy
A Krajcer, E Grzywna… - Biomedicine & …, 2023 - Elsevier
Glioblastoma (GBL) is the most common (60–70% of primary brain tumours) and the most
malignant of the glial tumours. Although current therapies remain palliative, they have been …
malignant of the glial tumours. Although current therapies remain palliative, they have been …
New opportunity to formulate intranasal vaccines and drug delivery systems based on chitosan
In an attempt to develop drug delivery systems that bypass the blood–brain barrier (BBB)
and prevent liver and intestinal degradation, it was concluded that nasal medication meets …
and prevent liver and intestinal degradation, it was concluded that nasal medication meets …