Lipid-based nanoparticles in the clinic and clinical trials: from cancer nanomedicine to COVID-19 vaccines

TTH Thi, EJA Suys, JS Lee, DH Nguyen, KD Park… - Vaccines, 2021 - mdpi.com
COVID-19 vaccines have been developed with unprecedented speed which would not have
been possible without decades of fundamental research on delivery nanotechnology. Lipid …

Solid lipid nanoparticles vs. nanostructured lipid carriers: a comparative review

C Viegas, AB Patrício, JM Prata, A Nadhman… - Pharmaceutics, 2023 - mdpi.com
Solid–lipid nanoparticles and nanostructured lipid carriers are delivery systems for the
delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures …

Astaxanthin activated the Nrf2/HO-1 pathway to enhance autophagy and inhibit ferroptosis, ameliorating acetaminophen-induced liver injury

X Cai, S Hua, J Deng, Z Du, D Zhang… - … Applied Materials & …, 2022 - ACS Publications
Acetaminophen (APAP)-induced liver injury (AILI) is a common liver disease in clinical
practice. Only one clinically approved drug, N-acetylcysteine (NAC), for the treatment of AILI …

Strategies for structural modification of small molecules to improve blood–brain barrier penetration: a recent perspective

B **ong, Y Wang, Y Chen, S **ng, Q Liao… - Journal of Medicinal …, 2021 - ACS Publications
In the development of central nervous system (CNS) drugs, the blood–brain barrier (BBB)
restricts many drugs from entering the brain to exert therapeutic effects. Although many …

Nanotherapeutics for nose-to-brain drug delivery: an approach to bypass the blood brain barrier

D Lee, T Minko - Pharmaceutics, 2021 - mdpi.com
Treatment of neurodegenerative diseases or other central nervous system (CNS) disorders
has always been a significant challenge. The nature of the blood-brain barrier (BBB) limits …

Current status and challenges associated with CNS-targeted gene delivery across the BBB

S Kimura, H Harashima - Pharmaceutics, 2020 - mdpi.com
The era of the aging society has arrived, and this is accompanied by an increase in the
absolute numbers of patients with neurological disorders, such as Alzheimer's disease (AD) …

Promising nanotechnology approaches in treatment of autoimmune diseases of central nervous system

M Chountoulesi, C Demetzos - Brain Sciences, 2020 - mdpi.com
Multiple sclerosis (MS) is a chronic, autoimmune, neurodegenerative disease of the central
nervous system (CNS) that yields to neuronal axon damage, demyelization, and paralysis …

Compritol-based nanostrucutured lipid carriers (NLCs) for augmentation of zolmitriptan bioavailability via the transdermal route: in vitro optimization, ex vivo …

DH Hassan, JN Shohdy, DA El-Setouhy… - Pharmaceutics, 2022 - mdpi.com
Migraine is a severe neurovascular disease manifested mainly as unilateral throbbing
headaches. Triptans are agonists for serotonin receptors. Zolmitriptan (ZMP) is a …

[HTML][HTML] Strategies increasing the effectiveness of temozolomide at various levels of anti-GBL therapy

A Krajcer, E Grzywna… - Biomedicine & …, 2023 - Elsevier
Glioblastoma (GBL) is the most common (60–70% of primary brain tumours) and the most
malignant of the glial tumours. Although current therapies remain palliative, they have been …

New opportunity to formulate intranasal vaccines and drug delivery systems based on chitosan

R Popescu, MV Ghica, CE Dinu-Pîrvu, V Anuța… - International Journal of …, 2020 - mdpi.com
In an attempt to develop drug delivery systems that bypass the blood–brain barrier (BBB)
and prevent liver and intestinal degradation, it was concluded that nasal medication meets …