Mammalian skeletal muscle comprises different fiber types, whose identity is first established
during embryonic development by intrinsic myogenic control mechanisms and is later …

The PGC-1 family of regulated coactivators, consisting of PGC-1α, PGC-1β and PRC, plays
a central role in a regulatory network governing the transcriptional control of mitochondrial …

Obesity and insulin resistance, the cardinal features of metabolic syndrome, are closely
associated with a state of low-grade inflammation,. In adipose tissue chronic overnutrition …

Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …

Proper function of the endoplasmic reticulum (ER) and mitochondria is crucial for cellular
homeostasis, and dysfunction at either site has been linked to pathophysiological states …

Type 2 diabetes mellitus (T2DM) is a systemic disease characterized by hyperglycemia,
hyperlipidemia, and organismic insulin resistance. This pathological shift in both circulating …

The study of human genetic disorders and mutant mouse models has provided evidence
that genome maintenance mechanisms, DNA damage signalling and metabolic regulation …

Macrophage infiltration and activation in metabolic tissues underlie obesity-induced insulin
resistance and type 2 diabetes. While inflammatory activation of resident hepatic …

Redox-dependent processes influence most cellular functions, such as differentiation,
proliferation, and apoptosis. Mitochondria are at the center of these processes, as …

Loss of muscle mass and force occurs in many diseases such as disuse/inactivity, diabetes,
cancer, renal, and cardiac failure and in aging-sarcopenia. In these catabolic conditions the …