Cyclooxygenases play a vital role in inflammation and are responsible for the production of
prostaglandins. Two cyclooxygenases are described, the constitutive cyclooxygenase-1 and …

Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …

One‐pot multi‐component reactions especially under transition‐metal‐free catalysis served
as an efficient, and environmentally friendly method for the construction of value‐added …

Numerous clinical disorders have been linked to the etiology of dysregulated NLRP3
(NACHT, LRR, and PYD domain‐containing protein 3) inflammasome activation. Despite its …

Background: A new set of hybrid conjugates derived from 2-(4-isobutylphenyl) propanoic
acid (ibuprofen) is synthesized to overcome the drawbacks of the current non-steroidal anti …

Herein, we describe a highly effective 1, 8-conjugate-addition-mediated formal (3+ 3)-
annulation of (aza)-para-quinone methides in situ generated from propargylic alcohols with …

For the first time, ruthenium-based assemblies have been used as carriers for
photosensitizers in the treatment of rheumatoid arthritis by photodynamic therapy (PDT) …

Fused pyranochromenone derivatives have extensive applications in medicinal chemistry.
Herein, we report the first HFIP/TsOH catalyzed, one-pot domino reaction by cleavage of the …

4-Hydroxycoumarin derivatives represent one of the most important scaffolds in biologically
active substances, pharmaceuticals and functional materials. Herein, we describe an …

The synthesis of pyranocoumarin is reported from 4-hydroxycoumarin, styrene oxide, and
DMSO in the presence of p-TSA· H2O at 110° C using a three-component reaction …