Pain is the major symptom of osteoarthritis (OA) and is an important factor in strategies to
manage this disease. However, the current standard of care does not provide satisfactory …

Neurotrophin signaling is essential for normal nervous system development and adult
function. Neurotrophins are secreted proteins that signal via interacting with two …

Allosteric modulators bound to structurally diverse allosteric sites can achieve better
pharmacological advantages than orthosteric ligands. The discovery of allosteric …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

Fragment molecular orbital (FMO) method is a powerful computational tool for structure‐
based drug design, in which protein–ligand interactions can be described by the inter …

Halopyridines are key building blocks for synthesizing pharmaceuticals, agrochemicals, and
ligands for metal complexes, but strategies to selectively halogenate pyridine C–H …

ABSTRACT Introduction The Trk family proteins are membrane-bound kinases
predominantly expressed in neuronal tissues. Activated by neurotrophins, they regulate …

On-target resistance to next-generation TRK inhibitors in TRK fusion–positive cancers is
largely uncharacterized. In patients with these tumors, we found that TRK xDFG mutations …