Recent advances in cancer immunotherapy—ranging from immune-checkpoint blockade
therapy to adoptive cellular therapy and vaccines—have revolutionized cancer treatment …

Cancers are highly complex diseases that are characterized by not only the overgrowth of
malignant cells but also an altered immune response. The inhibition and reprogramming of …

Recent advances in machine learning and experimental biology have offered breakthrough
solutions to problems such as protein structure prediction that were long thought to be …

Neoantigens play a key role in the recognition of tumour cells by T cells; however, only a
small proportion of neoantigens truly elicit T-cell responses, and few clues exist as to which …

BACKGROUND. Neoantigen-driven recognition and T cell–mediated killing contribute to
tumor clearance following adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes …

Recent advances in neoantigen research have accelerated the development and regulatory
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …

Surface modification of nanomaterials is essential for their biomedical applications owing to
their passive immune clearance and damage to reticuloendothelial systems. Recently, a cell …

Immunotherapies play critical roles in cancer treatment. However, given that only a few
patients respond to immune checkpoint blockades and other immunotherapeutic strategies …

Immunotherapies are yielding effective treatments for several previously untreatable
cancers. Still, the identification of suitable antigens specific to the tumour that can be targets …

Antigen discovery technologies have largely focused on major histocompatibility complex
(MHC) class I-restricted human T cell receptors (TCRs), leaving methods for MHC class II …