Implications of siRNA therapy in bone health: silencing communicates
The global statistics of bone disorders, skeletal defects, and fractures are frightening.
Several therapeutic strategies are being used to fix them; however, RNAi-based siRNA …
Several therapeutic strategies are being used to fix them; however, RNAi-based siRNA …
Exploring precision treatments in immune‐mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery
L Xu, Z Shao, X Fang, Z **n, S Zhao, H Zhang… - …, 2024 - Wiley Online Library
Immune‐mediated inflammatory diseases (IMIDs) impose an immeasurable burden on
individuals and society. While the conventional use of immunosuppressants and disease …
individuals and society. While the conventional use of immunosuppressants and disease …
Effects of chain lengths and backbone chirality on the bone-targeting ability of poly (glutamic acid) s
J **a, W Wang, X **, J Zhao, J Chen, N Li… - Biomaterials …, 2024 - pubs.rsc.org
Anionic synthetic polypeptides are promising candidates as standalone bone-targeting drug
carriers. Nevertheless, the structure-property relationship of the bone-targeting ability of …
carriers. Nevertheless, the structure-property relationship of the bone-targeting ability of …
Effect of Allele-Specific Clcn7G213R siRNA Delivered Via a Novel Nanocarrier on Bone Phenotypes in ADO2 Mice on 129S Background
S Saffie-Siebert, I Alam, FM Sutera, A Dehsorkhi… - Calcified Tissue …, 2024 - Springer
Autosomal dominant osteopetrosis type 2 (ADO2) is a rare inherited bone disorder
characterised by dense but brittle bones. It displays striking phenotypic variability, with the …
characterised by dense but brittle bones. It displays striking phenotypic variability, with the …
Biomimetic siRNA nanogels for regulating macrophage polarization and promoting osteogenesis
X Ma, Q Zhou, Z Liu, Y Wang, Y Hu - Heliyon, 2024 - cell.com
Background Bone fracture regeneration poses significant clinical challenges due to
complications such as delayed healing, nonunion, and the limitations of current treatments …
complications such as delayed healing, nonunion, and the limitations of current treatments …