Spermatogenesis is the cellular process by which spermatogonia develop into mature
spermatids within seminiferous tubules, the functional unit of the mammalian testis, under …

Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …

OBJECTIVE: To determine whether microRNAs are differentially expressed in men with
normal versus impaired spermatogenesis, and to find a biomarker for accurate diagnosis of …

The identification and physical isolation of testis stem cells, a subset of type A
spermatogonia, is critical to our understanding of their growth regulation during the first …

Retroviruses that have the ability to infect germ line cells can become an integral and
inherited part of the host genome. About 8% of the human chromosomal DNA consists of …

Mammalian spermatogenesis is a complex process in which male germ-line stem cells
develop to ultimately form spermatozoa. Spermatogonial stem cells, or SSCs, are found in …

The establishment and maintenance of spermatogenesis in mammals requires specialized
networks of gene expression programs in the testis. The gonad-specific TAF4b component …

Only few of the human endogenous retrovirus (HERV) sequences in the human genome can
produce proteins. We have previously reported that (i) patients with germ cell tumors often …

The correlation between epigenetic alterations and the pathophysiology of human infertility
is progressively being elucidated with the discovery of an increasing number of target genes …

Although present at relatively low number in the testis, spermatogonial stem cells (SSCs) are
crucial for the establishment and maintenance of spermatogenesis in eukaryotes and, until …