Gut microbiome lipid metabolism and its impact on host physiology
Metabolites produced by commensal gut microbes impact host health through their
recognition by the immune system and their influence on numerous metabolic pathways …
recognition by the immune system and their influence on numerous metabolic pathways …
Community guidelines for GPCR ligand bias: IUPHAR review 32
GPCRs modulate a plethora of physiological processes and mediate the effects of one‐third
of FDA‐approved drugs. Depending on which ligand activates a receptor, it can engage …
of FDA‐approved drugs. Depending on which ligand activates a receptor, it can engage …
Spatially resolved multiomics of human cardiac niches
The function of a cell is defined by its intrinsic characteristics and its niche: the tissue
microenvironment in which it dwells. Here we combine single-cell and spatial …
microenvironment in which it dwells. Here we combine single-cell and spatial …
GPCRdb in 2023: state-specific structure models using AlphaFold2 and new ligand resources
G protein-coupled receptors (GPCRs) are physiologically abundant signaling hubs routing
hundreds of extracellular signal substances and drugs into intracellular pathways. The …
hundreds of extracellular signal substances and drugs into intracellular pathways. The …
Common coupling map advances GPCR-G protein selectivity
Two-thirds of human hormones and one-third of clinical drugs act on membrane receptors
that couple to G proteins to achieve appropriate functional responses. While G protein …
that couple to G proteins to achieve appropriate functional responses. While G protein …
The 2022 Nucleic Acids Research database issue and the online molecular biology database collection
DJ Rigden, XM Fernández - Nucleic acids research, 2022 - academic.oup.com
Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …
87 papers reporting on new databases and 85 updates from resources previously published …
Autoregulation of GPCR signalling through the third intracellular loop
The third intracellular loop (ICL3) of the G protein-coupled receptor (GPCR) fold is important
for the signal transduction process downstream of receptor activation,–. Despite this, the lack …
for the signal transduction process downstream of receptor activation,–. Despite this, the lack …
Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs
C Avet, A Mancini, B Breton, C Le Gouill, AS Hauser… - Elife, 2022 - elifesciences.org
The recognition that individual GPCRs can activate multiple signaling pathways has raised
the possibility of develo** drugs selectively targeting therapeutically relevant ones. This …
the possibility of develo** drugs selectively targeting therapeutically relevant ones. This …
[HTML][HTML] Rules and mechanisms governing G protein coupling selectivity of GPCRs
G protein-coupled receptors (GPCRs) convert extracellular stimuli into intracellular signaling
by coupling to heterotrimeric G proteins of four classes: G i/o, G q, G s, and G 12/13 …
by coupling to heterotrimeric G proteins of four classes: G i/o, G q, G s, and G 12/13 …
Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine
J Zhao, H Fu, J Yu, W Hong, X Tian, J Qi, S Sun… - Nature …, 2023 - nature.com
Abstract Somatostatin receptor 2 (SSTR2) is highly expressed in neuroendocrine tumors
and represents as a therapeutic target. Several peptide analogs mimicking the endogenous …
and represents as a therapeutic target. Several peptide analogs mimicking the endogenous …