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[HTML][HTML] Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome
M Zoulikha, Q **ao, GF Boafo, MA Sallam… - … Pharmaceutica Sinica B, 2022 - Elsevier
The use of small interfering RNAs (siRNAs) has been under investigation for the treatment of
several unmet medical needs, including acute lung injury/acute respiratory distress …
several unmet medical needs, including acute lung injury/acute respiratory distress …
Spray freeze drying-a synergistic drying technology and its applications in the food industry to preserve bioactive compounds
In the food industry, drying is a crucial unit process for extending product shelf life. Many
methods are available for drying of foods but spray drying and freeze drying have been …
methods are available for drying of foods but spray drying and freeze drying have been …
[HTML][HTML] Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide
Pulmonary delivery of messenger RNA (mRNA) has considerable potential as therapy or
vaccine for a range of lung diseases. Inhaled dry powder formulation of mRNA is particularly …
vaccine for a range of lung diseases. Inhaled dry powder formulation of mRNA is particularly …
Physical stability of dry powder inhaler formulations
ABSTRACT Introduction: Dry powder inhalers (DPIs) are popular for pulmonary drug
delivery. Various techniques have been employed to produce inhalation drug particles and …
delivery. Various techniques have been employed to produce inhalation drug particles and …
Dry powder pharmaceutical biologics for inhalation therapy
Therapeutic biologics such as genes, peptides, proteins, virus and cells provide clinical
benefits and are becoming increasingly important tools in respiratory medicine. Pulmonary …
benefits and are becoming increasingly important tools in respiratory medicine. Pulmonary …
[HTML][HTML] Stabilizing vaccines via drying: Quality by design considerations
Pandemics and epidemics are continually challenging human beings' health and imposing
major stresses on the societies particularly over the last few decades, when their frequency …
major stresses on the societies particularly over the last few decades, when their frequency …
[HTML][HTML] Spray freeze-drying as a solution to continuous manufacturing of pharmaceutical products in bulk
Pharmaceutical manufacturing is evolving from traditional batch processes to continuous
ones. The new global competition focused on throughput and quality of drug products is …
ones. The new global competition focused on throughput and quality of drug products is …
Aerosolizable siRNA-encapsulated solid lipid nanoparticles prepared by thin-film freeze-drying for potential pulmonary delivery
Lipid nanoparticles are increasingly used for drug and gene delivery, including the delivery
of small interfering RNA (siRNA). Pulmonary delivery of drug molecules carried by lipid …
of small interfering RNA (siRNA). Pulmonary delivery of drug molecules carried by lipid …
Particle engineering principles and technologies for pharmaceutical biologics
The global market of pharmaceutical biologics has expanded significantly during the last few
decades. Currently, pharmaceutical biologic products constitute an indispensable part of the …
decades. Currently, pharmaceutical biologic products constitute an indispensable part of the …
Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury
Background Acute lung injury (ALI) is a life-threatening respiratory condition characterized
by severe inflammation and lung tissue damage, frequently causing rapid respiratory failure …
by severe inflammation and lung tissue damage, frequently causing rapid respiratory failure …