[HTML][HTML] Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome

M Zoulikha, Q **ao, GF Boafo, MA Sallam… - … Pharmaceutica Sinica B, 2022 - Elsevier
The use of small interfering RNAs (siRNAs) has been under investigation for the treatment of
several unmet medical needs, including acute lung injury/acute respiratory distress …

Spray freeze drying-a synergistic drying technology and its applications in the food industry to preserve bioactive compounds

N Chhabra, M Arora, D Garg, MK Samota - Food Control, 2024 - Elsevier
In the food industry, drying is a crucial unit process for extending product shelf life. Many
methods are available for drying of foods but spray drying and freeze drying have been …

[HTML][HTML] Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide

Y Qiu, RCH Man, Q Liao, KLK Kung, MYT Chow… - Journal of controlled …, 2019 - Elsevier
Pulmonary delivery of messenger RNA (mRNA) has considerable potential as therapy or
vaccine for a range of lung diseases. Inhaled dry powder formulation of mRNA is particularly …

Physical stability of dry powder inhaler formulations

N Shetty, D Cipolla, H Park, QT Zhou - Expert opinion on drug …, 2020 - Taylor & Francis
ABSTRACT Introduction: Dry powder inhalers (DPIs) are popular for pulmonary drug
delivery. Various techniques have been employed to produce inhalation drug particles and …

Dry powder pharmaceutical biologics for inhalation therapy

RYK Chang, MYT Chow, D Khanal, D Chen… - Advanced Drug Delivery …, 2021 - Elsevier
Therapeutic biologics such as genes, peptides, proteins, virus and cells provide clinical
benefits and are becoming increasingly important tools in respiratory medicine. Pulmonary …

[HTML][HTML] Stabilizing vaccines via drying: Quality by design considerations

Z Ghaemmaghamian, R Zarghami, G Walker… - Advanced Drug Delivery …, 2022 - Elsevier
Pandemics and epidemics are continually challenging human beings' health and imposing
major stresses on the societies particularly over the last few decades, when their frequency …

[HTML][HTML] Spray freeze-drying as a solution to continuous manufacturing of pharmaceutical products in bulk

MB Adali, AA Barresi, G Boccardo, R Pisano - Processes, 2020 - mdpi.com
Pharmaceutical manufacturing is evolving from traditional batch processes to continuous
ones. The new global competition focused on throughput and quality of drug products is …

Aerosolizable siRNA-encapsulated solid lipid nanoparticles prepared by thin-film freeze-drying for potential pulmonary delivery

JL Wang, MS Hanafy, H Xu, J Leal, Y Zhai… - International Journal of …, 2021 - Elsevier
Lipid nanoparticles are increasingly used for drug and gene delivery, including the delivery
of small interfering RNA (siRNA). Pulmonary delivery of drug molecules carried by lipid …

Particle engineering principles and technologies for pharmaceutical biologics

D Cun, C Zhang, H Bera, M Yang - Advanced Drug Delivery Reviews, 2021 - Elsevier
The global market of pharmaceutical biologics has expanded significantly during the last few
decades. Currently, pharmaceutical biologic products constitute an indispensable part of the …

Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury

SY Chen, YL Chen, PC Li, TS Cheng, YS Chu… - Journal of biomedical …, 2024 - Springer
Background Acute lung injury (ALI) is a life-threatening respiratory condition characterized
by severe inflammation and lung tissue damage, frequently causing rapid respiratory failure …