The musculoskeletal system supports the movement of the entire body and provides blood
production while acting as an endocrine organ. With aging, the balance of bone …

Background RNA-seq is widely used for transcriptomic profiling, but the bioinformatics
analysis of resultant data can be time-consuming and challenging, especially for biologists …

The human genome encodes a vast repertoire of protein non-coding RNAs (ncRNA), some
specific to the brain. MicroRNAs, which interfere with the translation of target mRNAs, are of …

Background The efficacy of cisplatin-based chemotherapy in non-small-cell lung cancer is
limited by the acquired drug resistance. Identification the RNAs related to the cisplatin …

Metformin, an oral hypoglycemic agent, has been used for decades to treat type 2 diabetes
mellitus. Recent studies indicate that mice treated with metformin live longer and have fewer …

Consumption of coffee, tea, wine, curry, and soybeans has been linked to a lower risk of
cancer in epidemiological studies. Several cell-based and animal studies have shown that …

MicroRNAs, a class of short endogenous RNAs, acting as post-transcriptional regulators of
gene expression, mostly silence gene expression via binding imperfectly matched …

ATP-binding cassette transporter A1 (ABCA1) is a cholesterol transporter that transfers
excess cellular cholesterol onto lipid-poor apolipoproteins. Given its critical role in …

Chemoresistance is one of the major hurdles to overcome for the successful treatment of
breast cancer. At present, there are several mechanisms proposed to explain drug …

MicroRNAs play a role in breast cancer development and progression by post-
transcriptional repression of the expression of important genes, such as the tumor …