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Advances and challenges in small‐molecule DNA aptamer isolation, characterization, and sensor development
Aptamers are short oligonucleotides isolated in vitro from randomized libraries that can bind
to specific molecules with high affinity, and offer a number of advantages relative to …
to specific molecules with high affinity, and offer a number of advantages relative to …
[HTML][HTML] Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis
M Zhao, R Wang, K Yang, Y Jiang, Y Peng, Y Li… - … Pharmaceutica Sinica B, 2023 - Elsevier
RNAs are involved in the crucial processes of disease progression and have emerged as
powerful therapeutic targets and diagnostic biomarkers. However, efficient delivery of …
powerful therapeutic targets and diagnostic biomarkers. However, efficient delivery of …
Thoughts on how to think (and talk) about RNA structure
Recent events have pushed RNA research into the spotlight. Continued discoveries of RNA
with unexpected diverse functions in healthy and diseased cells, such as the role of RNA as …
with unexpected diverse functions in healthy and diseased cells, such as the role of RNA as …
When will RNA get its AlphaFold moment?
The protein structure prediction problem has been solved for many types of proteins by
AlphaFold. Recently, there has been considerable excitement to build off the success of …
AlphaFold. Recently, there has been considerable excitement to build off the success of …
Advancement of the emerging field of RNA nanotechnology
The field of RNA nanotechnology has advanced rapidly during the past decade. A variety of
programmable RNA nanoparticles with defined shape, size, and stoichiometry have been …
programmable RNA nanoparticles with defined shape, size, and stoichiometry have been …
[PDF][PDF] Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions
The recent rapid development of single-particle electron cryo-microscopy (cryo-EM) now
allows structures to be solved by this method at resolutions close to 3 Å. Here, a number of …
allows structures to be solved by this method at resolutions close to 3 Å. Here, a number of …
Structures of the human and Drosophila 80S ribosome
Protein synthesis in all cells is carried out by macromolecular machines called ribosomes.
Although the structures of prokaryotic, yeast and protist ribosomes have been determined …
Although the structures of prokaryotic, yeast and protist ribosomes have been determined …
Automated 3D structure composition for large RNAs
Understanding the numerous functions that RNAs play in living cells depends critically on
knowledge of their three-dimensional structure. Due to the difficulties in experimentally …
knowledge of their three-dimensional structure. Due to the difficulties in experimentally …
RNA origami design tools enable cotranscriptional folding of kilobase-sized nanoscaffolds
RNA origami is a framework for the modular design of nanoscaffolds that can be folded from
a single strand of RNA and used to organize molecular components with nanoscale …
a single strand of RNA and used to organize molecular components with nanoscale …
A single-stranded architecture for cotranscriptional folding of RNA nanostructures
Artificial DNA and RNA structures have been used as scaffolds for a variety of nanoscale
devices. In comparison to DNA structures, RNA structures have been limited in size, but they …
devices. In comparison to DNA structures, RNA structures have been limited in size, but they …