Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …

Introduction: The enzyme carbonic anhydrase (CA, EC 4.2. 1.1) is found in numerous
organisms across the tree of life, with seven distinct classes known to date. CA inhibition can …

The methyl group is one of the most commonly occurring carbon fragments in small‐
molecule drugs. This simplest alkyl fragment appears in more than 67% of the top‐selling …

Introduction: The carbonic anhydrases (CAs, EC 4.2. 1.1), a group of ubiquitously expressed
metalloenzymes, are involved in numerous physiological and pathological processes, as …

Carbonic anhydrases (CAs, Enzyme Commission number 4.2. 1.1) catalyze a simple but
fundamental reaction, CO2 hydration to yield bicarbonate and protons. CAs belonging to the …

Chemical communication is a phenomenon exhibited by many different organisms and
nowadays is one of the most prominent research areas at the chemistry-microbiology …

Over the last decades, the medicinal chemistry of boron-based compounds has been
extensively explored, designing valuable small molecule drugs to tackle diseases and …

In this paper we report the synthesis of a series of benzoxaborole derivatives, their inhibition
properties against some carbonic anhydrases (CAs), recognized as important drug targets …

Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Benznidazole and nifurtimox are the two approved drugs for their treatment, but both …

Leishmaniasis is an infection provoked by protozoans belonging to the genus Leishmania.
Among the many species and subsepecies of such protozoa, Leishmania donovani chagasi …