Cancer reprogramming is an important facilitator of cancer development and survival, with
tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation …

Adeno-associated virus (AAV) is a small, nonenveloped virus that was adapted 30 years
ago for use as a gene transfer vehicle. It is capable of transducing a wide range of species …

Few transcription factors have been examined for their direct roles in physically connecting
enhancers and promoters. Here acute degradation of Yin Yang 1 (YY1) in erythroid cells …

There is considerable evidence that chromosome structure plays important roles in gene
control, but we have limited understanding of the proteins that contribute to structural …

Background Ocular neovascularization is a leading cause of blindness. Retinal microglia
have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the …

Although studies have identified hundreds of loci associated with human traits and diseases,
pinpointing causal alleles remains difficult, particularly for non-coding variants. To address …

Activation of hepatic stellate cells (HSCs) has been demonstrated to play a pivotal role in the
process of liver fibrogenesis. In this study, we observed a decrease in the expression of …

First described in 1991, Yin Yang 1 (YY1) is a transcription factor that is ubiquitously
expressed throughout mammalian cells. It regulates both transcriptional activation and …

CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …

The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on
helper factors to replicate. Those helper factors can be provided by coinfecting helper …