Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in
antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent …

This review will briefly outline the major signaling pathways in PMA-activated neutrophils.
PMA is widely used to understand neutrophil pathways and formation of NETs. PMA …

Neutrophils are the major circulating white blood cells in humans. They play an essential
role in host defense against pathogens. In healthy individuals, circulating neutrophils are in …

Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play
important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are …

Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases
including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil …

Neutrophils are produced in the bone marrow from stem cells that proliferate and
differentiate to mature neutrophils fully equipped with an armory of granules. These contain …

In the phagocytosis field, ROS production by the phagocyte NOX has been associated with
pathogen killing for the last 50 years. Since the discovery of nonphagocyte NOX, numerous …

Reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide (H 2 O
2) are thought to be byproducts of aerobic respiration with damaging effects on DNA …

For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …

Significance: Reactive oxygen species (ROS) play a critical role in vascular disease. While
there are many possible sources of ROS, nicotinamide adenine dinucleotide phosphate …