Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a
major cause of morbidity and mortality. The circadian timing system consists of a central …

The discovery of the genetic basis for circadian rhythms has expanded our knowledge of the
temporal organization of behavior and physiology. The observations that the circadian gene …

The CLOCK transcription factor is a key component of the molecular circadian clock within
pacemaker neurons of the hypothalamic suprachiasmatic nucleus. We found that …

In mammals, circadian control of physiology and behavior is driven by a master pacemaker
located in the suprachiasmatic nuclei (SCN) of the hypothalamus. We have used gene …

The importance of circadian biology has rarely been considered in pre-clinical studies, and
even more when translating to the bedside. Circadian biology is becoming a critical factor for …

Circadian timing is generated through a unique series of autoregulatory interactions termed
the molecular clock. Behavioral rhythms subject to the molecular clock are well …

Circadian rhythms occur in almost all species and control vital aspects of our physiology,
from slee** and waking to neurotransmitter secretion and cellular metabolism …

Background: The circadian timing system or circadian clock plays a crucial role in many
biological processes, such as the sleep-wake cycle, hormone secretion, cardiovascular …

Glucose tolerance is lower in the evening and at night than in the morning. However, the
relative contribution of the circadian system vs. the behavioral cycle (including the …

The circadian system serves one of the most fundamental properties present in nearly all
organisms: it generates 24-h rhythms in behavioral and physiological processes and …