Antibiotic resistance continues to plague antimicrobial chemotherapy of infectious disease.
And while true biocide resistance is as yet unrealized, in vitro and in vivo episodes of …

Multidrug efflux systems display the ability to transport a variety of structurally unrelated
drugs from a cell and consequently are capable of conferring resistance to a diverse range …

Background: The ansamycin class of antibiotics are produced by various Actinomycetes.
Their carbon framework arises from the polyketide pathway via a polyketide synthase (PKS) …

Here we describe repressible (PipOFF) as well as inducible (PipON) systems for regulated
gene expression in mammalian cells, based on the repressor Pip (pristinamycin-induced …

Streptogramins are potent drugs against numerous highly resistant pathogens and therefore
are used as antibiotics of last-resort human therapy. They consist of a mixture of two different …

Many secondary metabolites (eg antibiotics and mycotoxins) are toxic to the microorganisms
that produce them. The clusters of genes that are responsible for the biosynthesis of …

Many microbes synthesize potentially autotoxic antibiotics, mainly as secondary metabolites,
against which they need to protect themselves. This is done in various ways, ranging from …

Regulation of heterologous gene expression is of prime importance for a wide variety of
basic and applied biological research areas including functional genomics, tissue …

Glycosylation represents an attractive target for protein engineering of novel antibiotics,
because specific attachment of one or more deoxysugars is required for the bioactivity of …

The efflux systems of bacteria protect cells from antibiotics and biocides by actively
transporting compounds out of the cytoplasm and/or periplasm and thereby limit their steady …