Proximal telomeric decompaction due to telomere shortening drives FOXC1-dependent myocardial senescence

B Li, W **ong, W Zuo, Y Shi, T Wang… - Nucleic Acids …, 2024 - academic.oup.com
Telomeres, TTAGGGn DNA repeat sequences located at the ends of eukaryotic
chromosomes, play a pivotal role in aging and are targets of DNA damage response …

Distribution‐Agnostic Deep Learning Enables Accurate Single‐Cell Data Recovery and Transcriptional Regulation Interpretation

Y Su, Z Yu, Y Yang, KC Wong, X Li - Advanced Science, 2024 - Wiley Online Library
Single‐cell RNA sequencing (scRNA‐seq) is a robust method for studying gene expression
at the single‐cell level, but accurately quantifying genetic material is often hindered by …

The circular RNA circCPE regulates myoblast development by sponging miR-138

W Ru, A Qi, X Shen, B Yue, X Zhang, J Wang… - Journal of Animal …, 2021 - Springer
Background Skeletal muscle development, a long-term and complex process, is controlled
by a set of the myogenic genes. Circular RNAs (circRNAs), a class of noncoding RNA, have …

Tumor hypoxia regulates forkhead box C1 to promote lung cancer progression

YJ Lin, WC Shyu, CW Chang, CC Wang, CP Wu… - …, 2017 - pmc.ncbi.nlm.nih.gov
Forkhead box C1 (FOXC1) is a member of the forkhead family of transcription factors that are
characterized by a DNA-binding forkhead domain. Increasing evidence indicates that …

DNA methylation entropy is associated with DNA sequence features and developmental epigenetic divergence

Y Fang, Z Ji, W Zhou, J Abante… - Nucleic acids …, 2023 - academic.oup.com
Epigenetic information defines tissue identity and is largely inherited in development
through DNA methylation. While studied mostly for mean differences, methylation also …

[HTML][HTML] Role of fork-head box genes in breast cancer: From drug resistance to therapeutic targets

Sadaf, A Hazazi, SS Alkhalil, AA Alsaiari, AF Gharib… - Biomedicines, 2023 - mdpi.com
Breast cancer has been acknowledged as one of the most notorious cancers, responsible
for millions of deaths around the globe. Understanding the various factors, genetic …

Variants in FOXC1 and FOXC2 identified in patients with conotruncal heart defects

W Wei, B Li, F Li, K Sun, X Jiang, R Xu - Genomics, 2024 - Elsevier
Conotruncal heart defects (CTD), subtypes of congenital heart disease, result from abnormal
cardiac outflow tract development (OFT). FOXC1 and FOXC2 are closely related members of …