Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …

The incorporation of a synthetic, catalytically competent metallocofactor into a protein
scaffold to generate an artificial metalloenzyme (ArM) has been explored since the late …

The ability of one enzyme to catalyse multiple, mechanistically distinct transformations likely
played a crucial role in organisms' abilities to adapt to changing external stimuli in the past …

The design of artificial catalysts able to compete with the catalytic proficiency of enzymes is
an intense subject of research. Non-covalent interactions are thought to be involved in …

Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

Metalloproteins catalyse some of the most complex and important processes in nature, such
as photosynthesis and water oxidation. An ultimate test of our knowledge of how …

Enzymes are nanometer-sized molecules with three-dimensional structures created by the
folding and self-assembly of polymeric chain-like components through supramolecular …

During the recent past years, tremendous efforts have been made to establish
enantioselective routes for the preparation of enantiomerically pure compounds due to their …

When challenged by a difficult reduction reaction, a chemist should always also consider
biocatalysis in synthesis planning. The inherent selectivity of enzymes has been known for …

Transition metal catalysts and enzymes possess unique and often complementary
properties that have made them important tools for chemical synthesis. The potential …