Parkinson disease is characterized by dopaminergic cell loss in the substantia nigra of the
midbrain. There are various imaging markers for Parkinson disease. Recent advances in …

Parkinson disease (PD) is a progressive disorder characterized by dopaminergic
neurodegeneration in the brain. The development of parkinsonism is preceded by a long …

The diagnosis of Parkinson's disease (PD) occurs after pathogenesis is advanced and many
substantia nigra (SN) dopamine neurons have already died. Now that therapies to block this …

Noninvasive brain stimulation/modulation is a rapidly emerging technique that has been
implemented in different clinical applications. The commonly noninvasive techniques used …

The locus coeruleus (LC) contains norepinephrine (NE)-synthesizing neurons that send
diffuse projections throughout the central nervous system. The LC-NE system has a major …

The locus coeruleus (LC), a tiny nucleus in the brainstem and the principal site of
noradrenaline synthesis, has a major role in regulating autonomic function, arousal …

Background Development of reliable and accurate imaging biomarkers of dopaminergic cell
neurodegeneration is necessary to facilitate therapeutic drug trials in Parkinson's disease …

This study aimed to investigate the spatiotemporal changes in neuromelanin-sensitive MRI
signal in the substantia nigra and their relation to clinical scores of disease severity in …

Parkinson's disease (PD) is the second most common neurodegenerative disorder, globally
affecting men and women at an exponentially growing rate, with currently no cure. Disease …

In Parkinson's disease, there is a progressive reduction in striatal dopaminergic function,
and loss of neuromelanin-containing dopaminergic neurons and increased iron deposition …