Highlights•Locked nucleic acid-modified antisense oligonucleotides (LNAs) bind to and
modulate RNA.•The high binding affinity of LNAs significantly improves potency.•Structural …

This Account describes work done in these laboratories that has used synthetic, physical
organic, and biological chemistry to understand the roles played by the nucleobases …

Compositions comprising first and second oligomers are pro vided wherein at least a portion
of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at …

Cancer is responsible for about one in six deaths in the world. Conventional cancer
treatments like chemotherapy, radiotherapy, and surgery are associated with drug poisoning …

The COVID-19 pandemic is exacting an increasing toll worldwide, with new SARS-CoV-2
variants emerging that exhibit higher infectivity rates and that may partially evade vaccine …

Therapeutic oligonucleotides interact with a target RNA via Watson-Crick complementarity,
affecting RNA-processing reactions such as mRNA degradation, pre-mRNA splicing, or …

This review focuses on the potentials and perspectives of Locked Nucleic Acid (LNA)-based
oligonucleotides as therapeutic candidates. It briefly outlines various oligonucleotide-based …

We have used 2D NMR spectroscopy to study the sugar conformations of oligonucleotides
containing a conformationally restricted nucleotide (LNA) with a 2′‐O, 4′‐C‐methylene …

We have used NMR and CD spectroscopy to study the conformations of modified
oligonucleotides (locked nucleic acid, LNA) containing a conformationally restricted …

Abstract Adenosine Deaminases Acting on RNA (ADARs) are enzymes that catalyze the
conversion of adenosine to inosine in RNA duplexes. These enzymes can be harnessed to …