The nuclear hormone receptor superfamily includes receptors for thyroid and steroid
hormones, retinoids and vitamin D, as well as different “orphan” receptors of unknown …

Chromatin structure creates barriers for each step in eukaryotic transcription. Here we
discuss how the activities of two major classes of chromatin-modifying complexes, ATP …

Systematic interrogation of gene function requires the ability to perturb gene expression in a
robust and generalizable manner. Here we describe structure-guided engineering of a …

The transcription factors HNF3 (FoxA) and GATA-4 are the earliest known to bind the
albumin gene enhancer in liver precursor cells in embryos. To understand how they access …

Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant
phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin …

▪ Abstract It has been a long-standing challenge to decipher the principles that enable cells
to both organize their genomes into compact chromatin and ensure that the genetic …

The importance of histones and chromatin structure in the regulation of eukaryotic gene
transcription has become much more widely accepted over the past few years. It has been …

Transcription factors (TFs) regulate gene expression by binding to DNA sequences and
modulating transcriptional activity through their effector domains. Despite the central role of …

The functions of the SAGA and SWI/SNF complexes are interrelated and can form stable"
epigenetic marks" on promoters in vivo. Here we show that stable promoter occupancy by …