Cellular exposure to ionizing radiation leads to oxidizing events that alter atomic structure
through direct interactions of radiation with target macromolecules or via products of water …

Reactive oxygen species (ROS) are generated as by-products of cellular metabolism,
primarily in the mitochondria. When cellular production of ROS overwhelms its antioxidant …

Microglia mediate multiple facets of neuroinflammation, including cytotoxicity, repair,
regeneration, and immunosuppression due to their ability to acquire diverse activation …

A single mouse click on the topic tumor necrosis factor (TNF) in PubMed reveals about 50
000 articles providing one or the other information about this pleiotropic cytokine or its …

During apoptosis, mitochondrial membrane permeability (MMP) increases and the release
into the cytosol of pro-apoptotic factors (procaspases, caspase activators and caspase …

Cell death is an essential phenomenon in normal development and homeostasis, but also
plays a crucial role in various pathologies. Our understanding of the molecular mechanisms …

Contrary to previous dogmas, it is now well established that brain cells can produce
cytokines and chemokines, and can express adhesion molecules that enable an in situ …

In this review, we focus on lifestyle changes, especially dietary habits, that are at the basis of
chronic systemic low grade inflammation, insulin resistance and Western diseases. Our …

Out of the almost 17 members of the TNF superfamily, TNF is probably the most potent
inducer of apoptosis. TNF activates both cell-survival and cell-death mechanisms …

Increased reactive oxygen species generation by the leukocytes of the obese may be
responsible for increased oxidative injury to lipids and proteins and, hence, atherosclerosis …