Modulating biomolecular condensates: a novel approach to drug discovery
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …
been reported to play key roles in many cellular functions by compartmentalizing specific …
Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing
Biomolecular condensates are membraneless intracellular assemblies that often form via
liquid− liquid phase separation and have the ability to concentrate biopolymers. Research …
liquid− liquid phase separation and have the ability to concentrate biopolymers. Research …
Competing protein-RNA interaction networks control multiphase intracellular organization
Liquid-liquid phase separation (LLPS) mediates formation of membraneless condensates
such as those associated with RNA processing, but the rules that dictate their assembly …
such as those associated with RNA processing, but the rules that dictate their assembly …
Physical principles underlying the complex biology of intracellular phase transitions
Many biomolecular condensates appear to form via spontaneous or driven processes that
have the hallmarks of intracellular phase transitions. This suggests that a common …
have the hallmarks of intracellular phase transitions. This suggests that a common …
On the role of phase separation in the biogenesis of membraneless compartments
A Musacchio - The EMBO journal, 2022 - embopress.org
Molecular mechanistic biology has ushered us into the world of life's building blocks,
revealing their interactions in macromolecular complexes and inspiring strategies for …
revealing their interactions in macromolecular complexes and inspiring strategies for …
m6A enhances the phase separation potential of mRNA
Abstract N 6-methyladenosine (m6A) is the most prevalent modified nucleotide in mRNA,,
with around 25% of mRNAs containing at least one m6A. Methylation of mRNA to form m6A …
with around 25% of mRNAs containing at least one m6A. Methylation of mRNA to form m6A …
Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sites
Q Zheng, Y Chen, D Chen, H Zhao, Y Feng, Q Meng… - Cell, 2022 - cell.com
The mechanism that initiates autophagosome formation on the ER in multicellular organisms
is elusive. Here, we showed that autophagy stimuli trigger Ca 2+ transients on the outer …
is elusive. Here, we showed that autophagy stimuli trigger Ca 2+ transients on the outer …
[HTML][HTML] Molecular mechanisms of stress granule assembly and disassembly
Stress granules (SGs) are membrane-less ribonucleoprotein (RNP)-based cellular
compartments that form in the cytoplasm of a cell upon exposure to various environmental …
compartments that form in the cytoplasm of a cell upon exposure to various environmental …
The molecular language of membraneless organelles
Eukaryotic cells organize their intracellular components into organelles that can be
membrane-bound or membraneless. A large number of membraneless organelles, including …
membrane-bound or membraneless. A large number of membraneless organelles, including …
Tau protein liquid–liquid phase separation can initiate tau aggregation
The transition between soluble intrinsically disordered tau protein and aggregated tau in
neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau …
neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau …