Simple Summary Metallophores, which are secondary metabolites secreted by bacteria,
play an important role in their virulence. The bacterium Staphylococcus aureus produces …

Nicotianamine (NA) is a metabolite synthesized by all plants, in which it is involved in the
homeostasis of different micronutrients such as iron, nickel or zinc. In some plants it also …

Some transition metals, like manganese, iron, cobalt, nickel, copper and zinc, required for
the biosynthesis of metalloenzymes and metalloproteins, are essential micronutrients for the …

Highlights•Maintaining cellular metal bioavailability is a tightly regulated process.•Host-
mediated metal sequestration via calprotectin may result in multi-metal restriction.•The …

Metal ions such as zinc and copper play important roles in host–microbe interactions and
their availability can drastically affect the survival of pathogenic bacteria in a host niche …

Opines and opine‐type chemicals are valuable natural products with diverse biochemical
roles, and potential synthetic building blocks of bioactive compounds. Their synthesis …

To overcome the metal restriction imposed by the host's nutritional immunity, pathogenic
bacteria use high metal affinity molecules called metallophores. Metallophore‐mediated …

Staphylococcus aureus (S. aureus) infection is the most prevalent and resistant bacterial
infection, posing a worldwide health risk. Compared with healthy people, diabetes patients …

The host restricts the availability of zinc to prevent infection. To overcome this defense,
Staphylococcus aureus and Pseudomonas aeruginosa rely on zincophore-dependent zinc …

In metal-scarce environments, some pathogenic bacteria produce opine-type metallophores
mainly to face the host's nutritional immunity. This is the case of staphylopine, pseudopaline …