The TGFβ pathway has essential roles in embryonic development, organ homeostasis,
tissue repair and disease,. These diverse effects are mediated through the intracellular …

Artemisinin and its derivatives (ARTs) are the frontline drugs against malaria, but resistance
is jeopardizing their effectiveness. ART resistance is mediated by mutations in the parasite's …

RNA–protein interactions play an important role in numerous cellular processes in health
and disease. In recent years, the global RNA-bound proteome has been extensively studied …

Underlying the development of malaria parasites within erythrocytes and the resulting
pathogenicity is a hardwired program that secures proper timing of gene transcription and …

Transcription factors (TFs) are a family of DNA‐binding proteins whose gene regulatory
capabilities are of vital importance in defining the molecular state of a cell. Despite their …

Gene regulation is one of the most ubiquitous processes in biology. However, while the
catalog of bacterial genomes continues to expand rapidly, we remain ignorant about how …

In eukaryotes, the chromatin architecture has a pivotal role in regulating all DNA-associated
processes and it is central to the control of gene expression. For Plasmodium falciparum, a …

Taxon-specific proteins are key determinants defining the biology of all organisms and
represent prime drug targets in pathogens. However, lacking comparability with proteins in …

Interaction proteomics studies have provided fundamental insights into multimeric
biomolecular assemblies and cell-scale molecular networks. Significant recent …

High-resolution mass spectrometry (MS)-based proteomics is a powerful method for the
identification of soluble protein complexes and large-scale affinity purification screens can …