Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

In a world in which life expectancy is increasing, understanding and promoting healthy
aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade …

Time-restricted feeding (TRF) improves metabolic health. Both early TRF (eTRF, food intake
restricted to the early part of the day) and mid-day TRF (mTRF, food intake restricted to the …

Obesity and its complications have become a prominent global public health problem that
severely threatens human health. Melatonin, originally known as an effective antioxidant, is …

Melatonin, an indoleamine hormone produced and secreted at night by pinealocytes and
extra-pineal cells, plays an important role in timing circadian rhythms (24-h internal clock) …

Insomnia is a serious worldwide health threat, affecting nearly one third of the general
population. Melatonin has been reported to improve sleep efficiency and it was found that …

Pyroptosis is a proinflammatory form of cell death that is associated with pathogenesis of
many chronic inflammatory diseases. Melatonin is substantially reported to possess anti …

Epidemiological studies suggested an association between obesity and sleep disturbances.
Obstructive sleep apnea is the most prevalent type of obesity-related sleep disorder that …

Excess weight and obesity are severe public health threats worldwide. Recent evidence
demonstrates that gut microbiota dysbiosis contributes to obesity and its comorbidities. The …

Melatonin is a naturally occurring molecule secreted by the pineal gland and known as a
gatekeeper of circadian clocks. Mounting evidence indicates that melatonin, employing …