The neurobiology of activational aspects of motivation: exertion of effort, effort-based decision making, and the role of dopamine
Motivational processes are complex and multifaceted, with both directional and activational
aspects. Behavioral activation and exertion of effort are functions that enable organisms to …
aspects. Behavioral activation and exertion of effort are functions that enable organisms to …
Reward processing dysfunction in major depression, bipolar disorder and schizophrenia
New evidence of reward processing abnormalities in MDD, bipolar disorder and
schizophrenia has led to a greater understanding of the neural processes associated with …
schizophrenia has led to a greater understanding of the neural processes associated with …
The current conceptualization of negative symptoms in schizophrenia
Negative symptoms have long been conceptualized as a core aspect of schizophrenia. They
play a key role in the functional outcome of the disorder, and their management represents a …
play a key role in the functional outcome of the disorder, and their management represents a …
Cognitive effort: A neuroeconomic approach
Cognitive effort has been implicated in numerous theories regarding normal and aberrant
behavior and the physiological response to engagement with demanding tasks. Yet, despite …
behavior and the physiological response to engagement with demanding tasks. Yet, despite …
Inflammation effects on motivation and motor activity: role of dopamine
Motivational and motor deficits are common in patients with depression and other psychiatric
disorders, and are related to symptoms of anhedonia and motor retardation. These deficits in …
disorders, and are related to symptoms of anhedonia and motor retardation. These deficits in …
Reward processing and mood-related symptoms: An RDoC and translational neuroscience perspective
Background Two objectives of the NIMH Research Domain Criteria (RDoC) initiative are to
identify (a) mechanisms that are common to multiple psychiatric disorders, and (b) …
identify (a) mechanisms that are common to multiple psychiatric disorders, and (b) …
Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology
Motivation has been defined as the process that allows organisms to regulate their internal
and external environment, and control the probability, proximity and availability of stimuli. As …
and external environment, and control the probability, proximity and availability of stimuli. As …
A review of reward processing and motivational impairment in schizophrenia
This article reviews and synthesizes research on reward processing in schizophrenia, which
has begun to provide important insights into the cognitive and neural mechanisms …
has begun to provide important insights into the cognitive and neural mechanisms …
[HTML][HTML] Negative symptoms of schizophrenia: clinical characteristics, pathophysiological substrates, experimental models and prospects for improved treatment
MJ Millan, K Fone, T Steckler, WP Horan - European …, 2014 - Elsevier
Schizophrenia is a complex and multifactorial disorder generally diagnosed in young adults
at the time of the first psychotic episode of delusions and hallucinations. These positive …
at the time of the first psychotic episode of delusions and hallucinations. These positive …
Neural signatures of value comparison in human cingulate cortex during decisions requiring an effort-reward trade-off
Integrating costs and benefits is crucial for optimal decision-making. Although much is
known about decisions that involve outcome-related costs (eg, delay, risk), many of our …
known about decisions that involve outcome-related costs (eg, delay, risk), many of our …