B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

The acceleration of large-scale sequencing and the progress in high-throughput
computational analyses, defined as omics, was a hallmark for the comprehension of the …

Variation in the antibody response has been linked to differential outcomes in disease, and
suboptimal vaccine and therapeutic responsiveness, the determinants of which have not …

Adaptive immune receptor repertoires (AIRR) are key targets for biomedical research as
they record past and ongoing adaptive immune responses. The capacity of machine …

Abstract Machine learning is increasingly used to discover diagnostic and prognostic
biomarkers from high-dimensional molecular data. However, a variety of factors related to …

Together with environment and experience (that is to say, diet and training), the biological
and genetic make-up of an athlete plays a major role in exercise physiology. Sports …

Use of adaptive immune receptor repertoire sequencing (AIRR-seq) has become
widespread, providing new insights into the immune system with potential broad clinical and …

Background T cells play a key role in the pathogenesis of multiple sclerosis (MS), a chronic,
inflammatory, demyelinating disease of the central nervous system (CNS). Although several …

Background Machine learning (ML) methodology development for the classification of
immune states in adaptive immune receptor repertoires (AIRRs) has seen a recent surge of …

The adaptive immune system holds invaluable information on past and present immune
responses in the form of B and T cell receptor sequences, but we are limited in our ability to …