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[HTML][HTML] Recent advances in develo** small-molecule inhibitors against SARS-CoV-2
R **ang, Z Yu, Y Wang, L Wang, S Huo, Y Li… - … Pharmaceutica Sinica B, 2022 - Elsevier
The COVID-19 pandemic caused by the novel SARS-CoV-2 virus has caused havoc across
the entire world. Even though several COVID-19 vaccines are currently in distribution …
the entire world. Even though several COVID-19 vaccines are currently in distribution …
Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenal
Unprecedented efforts of the researchers have been witnessed in the recent past towards
the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit …
the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit …
[HTML][HTML] Promising terpenes as SARS-CoV-2 spike receptor-binding domain (RBD) attachment inhibitors to the human ACE2 receptor: Integrated computational …
The spike protein receptor binding domain (S-RBD) is a necessary corona-viral protein for
binding and entry of coronaviruses (COVs) into the host cells. Hence, it has emerged as an …
binding and entry of coronaviruses (COVs) into the host cells. Hence, it has emerged as an …
[HTML][HTML] Phytocompounds as potential inhibitors of SARS-CoV-2 Mpro and PLpro through computational studies
The inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main
protease (Mpro) and papain-like protease (PLpro) prevents viral multiplications; these viral …
protease (Mpro) and papain-like protease (PLpro) prevents viral multiplications; these viral …
USP2-related cellular signaling and consequent pathophysiological outcomes
H Kitamura, M Hashimoto - International Journal of Molecular Sciences, 2021 - mdpi.com
Ubiquitin specific protease (USP) 2 is a multifunctional deubiquitinating enzyme. USP2
modulates cell cycle progression, and therefore carcinogenesis, via the deubiquitination of …
modulates cell cycle progression, and therefore carcinogenesis, via the deubiquitination of …
USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice
Targeting angiotensin-converting enzyme 2 (ACE2) represents a promising and effective
approach to combat not only the COVID-19 pandemic but also potential future pandemics …
approach to combat not only the COVID-19 pandemic but also potential future pandemics …
Synthesis and crystal structures of new mixed-ligand schiff base complexes containing N-donor heterocyclic co-ligands: Molecular docking and pharmacophore …
Three new mixed-ligand copper (II) complexes (1–3) with NN'O type unsymmetrical
tridentate Schiff base ligands (SB) and N-donor heterocyclic co-ligands, with general …
tridentate Schiff base ligands (SB) and N-donor heterocyclic co-ligands, with general …
Main and papain-like proteases as prospective targets for pharmacological treatment of coronavirus SARS-CoV-2
LV Yevsieieva, KO Lohachova, A Kyrychenko… - RSC …, 2023 - pubs.rsc.org
The pandemic caused by the coronavirus SARS-CoV-2 led to a global crisis in the world
healthcare system. Despite some progress in the creation of antiviral vaccines and mass …
healthcare system. Despite some progress in the creation of antiviral vaccines and mass …
Zinc pyrithione is a potent inhibitor of PLPro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication
Abstract Zinc pyrithione (1a), together with its analogues 1b–h and ruthenium pyrithione
complex 2a, were synthesised and evaluated for the stability in biologically relevant media …
complex 2a, were synthesised and evaluated for the stability in biologically relevant media …
Synthesis, biological and computational studies of flavonoid acetamide derivatives
This study reports the synthesis and characterization of a novel class of flavonoid acetamide
derivatives (FA) of quercetin, apigenin, fisetin, kaempferol, and luteolin. Flavonoids display …
derivatives (FA) of quercetin, apigenin, fisetin, kaempferol, and luteolin. Flavonoids display …