DNA hypermethylation in disease: mechanisms and clinical relevance
M Ehrlich - Epigenetics, 2019 - Taylor & Francis
Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …
malignant diseases. This is consistent with numerous findings about differentiation …
Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health
Research efforts during the past decades have provided intriguing evidence suggesting that
stressful experiences during pregnancy exert long-term consequences on the future mental …
stressful experiences during pregnancy exert long-term consequences on the future mental …
[HTML][HTML] Benchmarking of Nanopore R10. 4 and R9. 4.1 flow cells in single-cell whole-genome amplification and whole-genome shotgun sequencing
Third-generation sequencing can be used in human cancer genomics and epigenomic
research. Oxford Nanopore Technologies (ONT) recently released R10. 4 flow cell, which …
research. Oxford Nanopore Technologies (ONT) recently released R10. 4 flow cell, which …
Methyl-CpG-binding domain proteins: readers of the epigenome
How DNA methylation is interpreted and influences genome regulation remains largely
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …
A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation
Abstract DNA 5-hydroxymethylcytosine (5hmC) modification is known to be associated with
gene transcription and frequently used as a mark to investigate dynamic DNA methylation …
gene transcription and frequently used as a mark to investigate dynamic DNA methylation …
New insights into 5hmC DNA modification: generation, distribution and function
Dynamic DNA modifications, such as methylation/demethylation on cytosine, are major
epigenetic mechanisms to modulate gene expression in both eukaryotes and prokaryotes. In …
epigenetic mechanisms to modulate gene expression in both eukaryotes and prokaryotes. In …
[HTML][HTML] MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling
Tumor cells metastasize to distant organs through genetic and epigenetic alterations,
including changes in microRNA (miR) expression. Here we find miR-22 triggers epithelial …
including changes in microRNA (miR) expression. Here we find miR-22 triggers epithelial …
Genome-wide detection of cytosine methylation by single molecule real-time sequencing
5-Methylcytosine (5mC) is an important type of epigenetic modification. Bisulfite sequencing
(BS-seq) has limitations, such as severe DNA degradation. Using single molecule real-time …
(BS-seq) has limitations, such as severe DNA degradation. Using single molecule real-time …
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX
Abstract TET (ten-eleven-translocation) proteins are Fe (ii)-and α-ketoglutarate-dependent
dioxygenases,, that modify the methylation status of DNA by successively oxidizing 5 …
dioxygenases,, that modify the methylation status of DNA by successively oxidizing 5 …
Phthalate exposure and long-term epigenomic consequences: a review
Phthalates are esters of phthalic acid which are used in cosmetics and other daily personal
care products. They are also used in polyvinyl chloride (PVC) plastics to increase durability …
care products. They are also used in polyvinyl chloride (PVC) plastics to increase durability …