Pathophysiology and treatment of diabetic retinopathy

F Bandello, R Lattanzio, I Zucchiatti, C Del Turco - Acta diabetologica, 2013 - Springer
In the past years, the management of diabetic retinopathy (DR) relied primarily on a good
systemic control of diabetes mellitus, and as soon as the severity of the vascular lesions …

Recent advances in understanding the biochemical and molecular mechanism of diabetic retinopathy

MS Ola, MI Nawaz, MM Siddiquei, S Al-Amro… - Journal of Diabetes and …, 2012 - Elsevier
One of the major complications in patients with diabetes is diabetic retinopathy (DR), a
leading cause of blindness worldwide. It takes several years before any clinical signs of …

Diabetic retinopathy–biomolecules and multiple pathophysiology

H Ahsan - Diabetes & Metabolic Syndrome: Clinical Research & …, 2015 - Elsevier
One of the major complications in patients with diabetes is diabetic retinopathy (DR), a
leading cause of blindness worldwide. It causes visual impairment and finally blindness, a …

Status of B-vitamins and homocysteine in diabetic retinopathy: association with vitamin-B12 deficiency and hyperhomocysteinemia

A Satyanarayana, N Balakrishna, S Pitla, PY Reddy… - PloS one, 2011 - journals.plos.org
Diabetic retinopathy (DR) is a common cause of blindness. Although many studies have
indicated an association between homocysteine and DR, the results so far have been …

Serum homocysteine level and gestational diabetes mellitus: A meta‐analysis

T Gong, J Wang, M Yang, Y Shao, J Liu… - Journal of diabetes …, 2016 - Wiley Online Library
Abstract Aims/Introduction Homocysteine levels during pregnancy in women with gestational
diabetes mellitus (GDM) have been studied; however, it remains unclear whether …

Neurodegeneration and neuroprotection in diabetic retinopathy

MS Ola, MI Nawaz, HA Khan, AS Alhomida - International Journal of …, 2013 - mdpi.com
Diabetic retinopathy is widely considered to be a neurovascular disease. This is in contrast
to its previous identity as solely a vascular disease. Early in the disease progression of …

[HTML][HTML] Regulation of lysyl oxidase-like 1 (LOXL1) and elastin-related genes by pathogenic factors associated with pseudoexfoliation syndrome

M Zenkel, A Krysta, F Pasutto… - … & visual science, 2011 - tvst.arvojournals.org
Purpose.: Pseudoexfoliation (PEX) syndrome/glaucoma is a complex, late-onset disorder of
the elastic fiber system. Strong genetic risk is conferred by the lysyl oxidase-like 1 (LOXL1) …

Role of elastic fiber degradation in disease pathogenesis

G Halsey, D Sinha, S Dhital, X Wang… - Biochimica et Biophysica …, 2023 - Elsevier
Elastin is a crucial extracellular matrix protein that provides structural integrity to tissues.
Crosslinked elastin and associated microfibrils, named elastic fiber, contribute to …

Association between homocysteine level and the risk of diabetic retinopathy: a systematic review and meta-analysis

X Lei, G Zeng, Y Zhang, Q Li, J Zhang, Z Bai… - Diabetology & metabolic …, 2018 - Springer
Background Previous studies have demonstrated that elevated homocysteine (Hcy) level
represents an independent risk factor for macrovascular disease. However, the relationship …

Emerging roles of lysyl oxidases in the cardiovascular system: new concepts and therapeutic challenges

J Martínez-González, S Varona, L Cañes, M Galán… - Biomolecules, 2019 - mdpi.com
Lysyl oxidases (LOX and LOX-likes (LOXLs) isoenzymes) belong to a family of copper-
dependent enzymes classically involved in the covalent cross-linking of collagen and …